Evidence map›Paper›PMID 34221003›Full record

ArticleNeural plasticity2021

Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/

Jin Huang, Liang Zhou, Jilin Chen, Tingbao Chen, Bo Lei, Niandong Zheng, Xiaoqiang Wan, Jianguo Xu, Tinghua Wang

Open access · goldAbstract read
In one paragraph

Article in Neural plasticity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Flavonoids ofPreventive nutrition and food science · 2026
    Article
  4. Article
  5. Hyperoside AlleviatesPolish journal of microbiology · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Research advances ofFrontiers in immunology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Neuro-Nutraceutical Polyphenols: How Far Are We?Antioxidants (Basel, Switzerland) · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. History and main research of psychoneuroimmunology in China.Brain, behavior, & immunity - health · 2022
    Article
  18. Review
  19. Article
  20. [Hyperoside protects mouse spermatocytes GC-2 cells from oxidative damage by activating the Keap1/Nrf2/HO-1 pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jin Huang *Institute of Neuroscience, Basic Medical College, Kunming Medical University, Kunming, Yunnan 650500, China.
Liang Zhou *Department of Neurology, Zhenxiong County People Hospital, Zhaotong, Yunnan Province, China.
Jilin ChenDepartment of Animal Zoology, Kunming Medical University, Kunming, Yunnan Province, China.
Tingbao ChenDepartment of Animal Zoology, Kunming Medical University, Kunming, Yunnan Province, China.
Bo LeiDepartment of Neurosurgery, West-China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Niandong ZhengNeurosurgery of the People's Hospital of Leshan, Leshan 614000, China.
Xiaoqiang WanNeurosurgery of the People's Hospital of Leshan, Leshan 614000, China.
Jianguo XuDepartment of Neurosurgery, West-China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Tinghua WangInstitute of Neuroscience, Basic Medical College, Kunming Medical University, Kunming, Yunnan 650500, China.ORCID 0000-0002-4665-0282
Kunming Medical University · CNPeople's Hospital of Bishan District · CNSichuan University · CNZhaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation plays important roles in the pathogenesis and progression of altered neurodevelopment, sensorineural hearing loss, and certain neurodegenerative diseases. Hyperoside (quercetin-3-O-

Indexed as

AnimalsApoptosisCell LineCytokinesDrug Evaluation, PreclinicalHedgehog ProteinsInflammationLipopolysaccharidesMiceNerve Growth FactorsNeuronsOxidative StressQuercetinSignal TransductionSirtuin 1Up-RegulationCytokinesHedgehog ProteinshyperosideLipopolysaccharidesNerve Growth FactorsQuercetinShh protein, mouseSirtuin 1

Identifiers

PMID34221003
PMCPMC8213468
OpenAlexW3166300015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.