Evidence map›Paper›PMID 34220915›Full record

ArticleFrontiers in plant science2021

Overcoming Bottlenecks for Metabolic Engineering of Sesquiterpene Production in Tomato Fruits.

Michael Gutensohn, Laura K Henry, Scott A Gentry, Joseph H Lynch, Thuong T H Nguyen, Eran Pichersky, Natalia Dudareva

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Sensory-Chemical Co-Dynamics inFoods (Basel, Switzerland) · 2025
    Article
  2. Volatile organic compounds inHorticulture research · 2025
    Article
  3. Article
  4. Article
  5. Functional Analysis ofInternational journal of molecular sciences · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Michael GutensohnDivision of Plant and Soil Sciences, West Virginia University, Morgantown, WV, United States.
Laura K HenryDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Scott A GentryDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Joseph H LynchDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Thuong T H NguyenDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Eran PicherskyDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Natalia DudarevaDepartment of Biochemistry, Purdue University, West Lafayette, IN, United States.
Purdue University West Lafayette · USUniversity of Michigan–Ann Arbor · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Terpenoids are a large and diverse class of plant metabolites that also includes volatile mono- and sesquiterpenes which are involved in biotic interactions of plants. Due to the limited natural availability of these terpenes and the tight regulation of their biosynthesis, there is strong interest to introduce or enhance their production in crop plants by metabolic engineering for agricultural, pharmaceutical and industrial applications. While engineering of monoterpenes has been quite successful, expression of sesquiterpene synthases in engineered plants frequently resulted in production of only minor amounts of sesquiterpenes. To identify bottlenecks for sesquiterpene engineering in plants, we have used two nearly identical terpene synthases, snapdragon (

Indexed as

isopentenyl phosphate kinaseMEP pathwaymetabolic engineeringmonoterpenesMVA pathwaynerolidol/linalool synthasesesquiterpenestomato fruit

Identifiers

PMID34220915
PMCPMC8248349
OpenAlexW3176166370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.