ReviewFrontiers in immunology2021
Phytogenic Bioactive Compounds Shape Fish Mucosal Immunity.
Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 117 citations in OpenAlex.
- Corn husk meal as a sustainable dietary additive in biofloc-cultured koi carp (Cyprinus carpio var. koi): Integrative effects on growth performance, immune response, histology, gene expression, and ammonia-stress resilience.Veterinary research communications · 2026Article
- Natural Antioxidants and Aquatic Animal Health-2nd Edition.Antioxidants (Basel, Switzerland) · 2026Article
- Dietary Inulin Modulates Intestinal Health and Muscle Nutritional Composition in Juvenile Silver Pomfret (Foods (Basel, Switzerland) · 2026Article
- Nutritional detoxification strategies in aquaculture: bioactive feed additives mitigating oxidative stress and xenobiotic toxicity in fish.Fish physiology and biochemistry · 2026Review
- Effects of Dietary Nucleotides on Growth Performance, Antioxidant Capacity, Intestinal Morphology and Gut Microbiota of Swamp Eel (Animals : an open access journal from MDPI · 2026Article
- Potential Role of Brown Macroalgae on Pig Health: A Review.ACS nutrition science · 2026Review
- Functional Evaluation of Pomegranate (Antioxidants (Basel, Switzerland) · 2026Article
- Looking for Greener Pastures: In Vitro Screening of Phytogenics for the Control of Sparicotyle chrysophrii in Gilthead Sea Bream.Journal of fish diseases · 2026Article
- Organosulfur compounds as dual-action agents: a critical review of antimicrobial and immunomodulatory potentials, and translational barriers.Frontiers in pharmacology · 2026Review
- Microencapsulated Botanicals and Organic Acids Improve Immune Status and Growth in Gilthead Seabream (Aquaculture nutrition · 2026Article
- Dietary responses of taste receptor genes to plant-based diets in farmed fish: A literature review.Open veterinary journal · 2026Review
- Functional Feeds as Immunostimulants for Aquaculture: A Molecular Perspective.Aquaculture nutrition · 2026Review
- Mitigating antimicrobial resistance in the animal industry: reduction strategies and alternatives to antibiotics.Frontiers in veterinary science · 2026Review
- Effect of Dietary Supplementation with Red-Fleshed Dragon Fruit (Antioxidants (Basel, Switzerland) · 2025Article
- Protective Role ofMicroorganisms · 2025Article
- All that glitters is not gold: towards the standardization of experimental trials assessing functional feeds with immunomodulatory properties.Fish physiology and biochemistry · 2025Review
- Article
- Anatomical site and environmental exposure differentially shape the microbiota across mucosal tissues in rainbow trout (Oncorhynchus mykiss).Scientific reports · 2025Article
- Phytogenic Feed Additives as a Sustainable Alternative to Antibiotics: Enhancing Growth and Disease Resistance in Nile Tilapia (Animals : an open access journal from MDPI · 2025Article
- Effect of Oregano Essential Oil on Growth and Composition of Gut Prokaryote Microbiota on Striped Bass (Microorganisms · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaculture growth will unavoidably involve the implementation of innovative and sustainable production strategies, being functional feeds among the most promising ones. A wide spectrum of phytogenics, particularly those containing terpenes and organosulfur compounds, are increasingly studied in aquafeeds, due to their growth promoting, antimicrobial, immunostimulant, antioxidant, anti-inflammatory and sedative properties. This trend relies on the importance of the mucosal barrier in the fish defense. Establishing the phytogenics' mode of action in mucosal tissues is of importance for further use and safe administration. Although the impact of phytogenics upon fish mucosal immunity has been extensively approached, most of the studies fail in addressing the mechanisms underlying their pharmacological effects. Unstandardized testing as an extended practice also questions the reproducibility and safety of such studies, limiting the use of phytogenics at commercial scale. The information presented herein provides insight on the fish mucosal immune responses to phytogenics, suggesting their mode of action, and ultimately encouraging the practice of reliable and reproducible research for novel feed additives for aquafeeds. For proper screening, characterization and optimization of their mode of action, we encourage the evaluation of purified compounds using
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.