Evidence map›Paper›PMID 34220848›Full record

ArticleFrontiers in immunology2021

Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes.

Laura Ardighieri, Francesco Missale, Mattia Bugatti, Luisa Benerini Gatta, Irene Pezzali, Matilde Monti, Stefano Gottardi, Laura Zanotti, Eliana Bignotti, Antonella Ravaggi and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  7. Frontiers in immunology · 2026
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  14. Development of DPP-4-resistant CXCL9-Fc and CXCL10-Fc chemokines for effective cancer immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  17. TREM2Frontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 4 countries.

Laura ArdighieriUnit of Pathology, ASST Spedali Civili di Brescia, Brescia, Italy.
Francesco MissaleDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Mattia BugattiUnit of Pathology, ASST Spedali Civili di Brescia, Brescia, Italy.
Luisa Benerini GattaDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Irene PezzaliDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Matilde MontiDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Stefano GottardiDiatech Pharmacogenetics srl, Jesi, Italy.
Laura Zanotti'Angelo Nocivelli" Institute of Molecular Medicine, ASST Spedali Civili of Brescia- University of Brescia, Brescia, Italy.
Eliana Bignotti'Angelo Nocivelli" Institute of Molecular Medicine, ASST Spedali Civili of Brescia- University of Brescia, Brescia, Italy.
Antonella Ravaggi'Angelo Nocivelli" Institute of Molecular Medicine, ASST Spedali Civili of Brescia- University of Brescia, Brescia, Italy.
Germana TognonDivision of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, Brescia, Italy.
Franco OdicinoDivision of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, Brescia, Italy.
Stefano CalzaUnit of Biostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Yoann Missolo-KoussouPSL University, Institut Curie Research Center, INSERM U932 & SiRIC, Center for Cancers Immunotherapy, Translational Immunotherapy Team, Paris, France.
Carola Hermine RiesDr. Carola Ries Consulting, Penzberg, Germany.
Julie HelftPSL University, Institut Curie Research Center, INSERM U932 & SiRIC, Center for Cancers Immunotherapy, Translational Immunotherapy Team, Paris, France.
William VermiUnit of Pathology, ASST Spedali Civili di Brescia, Brescia, Italy.
University of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITInserm · FRUniversité Paris Sciences et Lettres · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian carcinomas (OCs) are poorly immunogenic and immune checkpoint inhibitors (ICIs) have offered a modest benefit. In this study, high CD3

Indexed as

Tumor MicroenvironmentAgedAntigens, CDAntigens, Differentiation, MyelomonocyticCarcinomaCD163 AntigenCD3 ComplexCells, CulturedChemokine CXCL10Drug Resistance, NeoplasmFemaleHumansInterferon Regulatory Factor-1Lymphocytes, Tumor-InfiltratingMembrane GlycoproteinsMiddle AgedAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCD3 ComplexChemokine CXCL10CXCL10 protein, humanInterferon Regulatory Factor-1IRF1 protein, humanMembrane GlycoproteinsReceptors, Cell SurfaceReceptors, ImmunologicSTAT1 protein, humanSTAT1 Transcription FactorTREM2 protein, humanCXCL10macrophageovarian cancerpolarizationsignature

Identifiers

PMID34220848
PMCPMC8253056
OpenAlexW3177377060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.