Evidence map›Paper›PMID 34220845›Full record

ArticleFrontiers in immunology2021

Response to Oxidative Burst-Induced Hypoxia Is Associated With Macrophage Inflammatory Profiles as Revealed by Cellular Genome-Wide Association.

Mehdi Emam, Saeid Tabatabaei, Mehdi Sargolzaei, Bonnie Mallard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Macrophages: sentinels, warriors, and healers.Human molecular genetics · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Ferroptosis and its relationship with cancer.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mehdi EmamDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Saeid TabatabaeiDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Mehdi SargolzaeiDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Bonnie MallardDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
University of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In mammalian species, hypoxia is a prominent feature of inflammation. The role of hypoxia in regulating macrophage responses Material and Methods: In the current study, the association between 43,066 autosomal Single Nucleic Polymorphism (SNPs) and the ability of MDMs in production of NO Results: Sixty SNPs on 22 chromosomes of the bovine genome were found to be significantly associated with NO Conclusion: The results suggest that the genetic polymorphism

Indexed as

Polymorphism, Single NucleotideRespiratory BurstAnimalsCattleCell HypoxiaCells, CulturedEscherichia coliEscherichia coli InfectionsGene Regulatory NetworksGenome-Wide Association StudyHost-Pathogen InteractionsInflammationInflammation MediatorsMacrophagesNitric OxidePhagocytosisInflammation MediatorsNitric OxideE. coligenetic regulationhypoixa-inducible factorinflammationmacrophage

Identifiers

PMID34220845
PMCPMC8253053
OpenAlexW3175387846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.