Evidence map›Paper›PMID 34220832›Full record

ReviewFrontiers in immunology2021

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Teresa Rodriguez-Calvo, Gustaf Christoffersson, Christine Bender, Matthias G von Herrath, Roberto Mallone, Sally C Kent, Eddie A James

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Gut-tropic α4β7Frontiers in immunology · 2025
    Article
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  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Teresa Rodriguez-CalvoInstitute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
Gustaf ChristofferssonScience for Life Laboratory, Uppsala University, Uppsala, Sweden.
Christine BenderCenter for Autoimmunity and Inflammation, Type 1 Diabetes Center at La Jolla Institute for Immunology, La Jolla, CA, United States.
Matthias G von HerrathCenter for Autoimmunity and Inflammation, Type 1 Diabetes Center at La Jolla Institute for Immunology, La Jolla, CA, United States.
Roberto MalloneUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Sally C KentDepartment of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, United States.
Eddie A JamesTranslatonal Research Program, Benaroya Research Institute, Seattle WA, United States.
La Jolla Institute for Immunology · USBenaroya Research InstituteDeutsches Diabetes-Zentrum e.V. · DEInserm · FRUniversity of Massachusetts Chan Medical School · USUppsala University · SE

Funding

Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).U24DK104162 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI John S. Kaddis, Joyce Carol Niland · 2019 to 2026
$12.3M
Specificity, Phenotype and Function of Pancreatic CD8 T Cells in Human Type 1 DiabetesR01AI092453 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Estefania Quesada Masachs · 2011 to 2026
$5.7M
Integrated Functional Histopathology of the Diabetic Human PancreasR01AI134971 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOMANN, DIRK, VON HERRATH, MATTHIAS G. · 2018 to 2022
$3.5M
Human Islet-Infiltrating T Cell Biology: Reactivity, Structure, and FunctionUC4DK116284 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARLAN, DAVID MARSHALL, KENT, SALLY CHOATE · 2017 to 2017
$2.0M
NIAID NIH HHS R01 AI092453NIAID NIH HHS R01 AI134971NIDDK NIH HHS U24 DK104162NIDDK NIH HHS UC4 DK116284
6 · The paper itself

Abstract

In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8

Indexed as

Disease SusceptibilityAnimalsAutoimmunityBiomarkersCell CommunicationCellular MicroenvironmentDiabetes Mellitus, Type 1Disease Models, AnimalHumansIslets of LangerhansT-Lymphocyte SubsetsBiomarkersautoreactive T cellsinsulitisnon-islet reactive T cellstype 1 diabetesβ cell destruction

Identifiers

PMID34220832
PMCPMC8242234
OpenAlexW3166770494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.