Evidence map›Paper›PMID 34220814›Full record

ArticleFrontiers in immunology2021

NLRP3 Regulates IL-4 Expression in TOX

Enrique Huanosta-Murillo, Marcela Alcántara-Hernández, Brenda Hernández-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, María Antonieta Domínguez-Gómez, Fermín Jurado-Santacruz, Genaro Patiño-López, Vadim Pérez-Koldenkova, Alam Palma-Guzmán and 4 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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  14. The inflammasomes: crosstalk between innate immunity and hematology.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  15. Inflammasomes-New Contributors to Blood Diseases.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Enrique Huanosta-MurilloUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Marcela Alcántara-HernándezDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, United States.
Brenda Hernández-RicoUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Georgina Victoria-AcostaUnidad de Investigación, Hospital Juárez de México, Mexico City, Mexico.
Patricia Miranda-CruzDepartamento de Biología Celular, Centro de Investigación y Estudios Avanzados, Instituto Politécnico Nacional, Mexico City, Mexico.
María Antonieta Domínguez-GómezCentro Dermatológico Dr. Ladislao de la Pascua, Secretaría de Salud de la Ciudad de México, Mexico City, Mexico.
Fermín Jurado-SantacruzCentro Dermatológico Dr. Ladislao de la Pascua, Secretaría de Salud de la Ciudad de México, Mexico City, Mexico.
Genaro Patiño-LópezLaboratorio de Investigación en Inmunología y Proteómica, Sección de Biología Celular de Linfocitos, Unidad de Hemato-Oncología e Investigación Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Vadim Pérez-KoldenkovaLaboratorio Nacional de Microscopía Avanzada, División de Desarrollo de la Investigación, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Alam Palma-GuzmánLaboratorio de Histología, Coordinación de Investigación en Salud, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Paula Licona-LimónDepartamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Ezequiel M Fuentes-PananáUnidad de Investigación en Virología y Cáncer, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Alicia Lemini-LópezServicio de Dermatología, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Laura C BonifazUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Centro Medico Nacional Siglo XXI · MXHospital Infantil de México Federico Gómez · MXSecretaria de Salud · MXHospital Juárez de México · MXInstituto Politécnico Nacional · MXStanford University · USUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed. Moreover, although the production and regulation of IL-4 expression during the early stages of the disease may have important implications in later stages, these processes are poorly understood. Here, we demonstrate the presence of TOX

Indexed as

CD4-Positive T-LymphocytesCell ProliferationCytotoxicity, ImmunologicDisease ProgressionGene Expression Regulation, NeoplasticHumansInterleukin-4Jurkat CellsLymphocytes, Tumor-InfiltratingLymphoma, T-Cell, CutaneousMexicoNLR Family, Pyrin Domain-Containing 3 ProteinPhenotypeSignal TransductionSkin NeoplasmsIL4 protein, humanInterleukin-4NLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanCutaneous T cell lymphomaInterleukin-4NLRP3Skin lesionTh2 cytokinesT helper T cell

Identifiers

PMID34220814
PMCPMC8244903
OpenAlexW3166798002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.