Evidence map›Paper›PMID 34220799›Full record

ArticleFrontiers in immunology2021

Genetic Variants in

Chao Shen, Zhijun Ge, Chen Dong, Chunhui Wang, Jianguo Shao, Weihua Cai, Peng Huang, Haozhi Fan, Jun Li, Yun Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Impact ofFrontiers in cellular and infection microbiology · 2026
    Article
  4. The Role of Killer Ig-like Receptors in Diseases from A to Z.International journal of molecular sciences · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Chao ShenDepartment of Epidemiology and Biostatistics, Key Laboratory of Infectious Diseases, School of Public Health, Nanjing Medical University, Nanjing, China.
Zhijun GeDepartment of Critical Care Medicine, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China.
Chen DongDepartment of Epidemiology and Statistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Chunhui WangInstitute of Epidemiology and Microbiology, Eastern Theater Command Centers for Disease Control and Prevention, Nanjing, China.
Jianguo ShaoDepartment of Digestive Medicine, Third Affiliated Hospital of Nantong University, Nantong, China.
Weihua CaiDepartment of General Surgery, Third Affiliated Hospital of Nantong University, Nantong, China.
Peng HuangDepartment of Epidemiology and Biostatistics, Key Laboratory of Infectious Diseases, School of Public Health, Nanjing Medical University, Nanjing, China.
Haozhi FanDepartment of Information, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jun LiDepartment of Infectious Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yun ZhangInstitute of Epidemiology and Microbiology, Eastern Theater Command Centers for Disease Control and Prevention, Nanjing, China.
Ming YueDepartment of Infectious Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNWuxi Third People's Hospital · CNJiangsu Province Hospital · CNSoochow University · CNYixing People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: KIR/HLA-C signaling pathway influences the innate immune response which is the first defense to hepatitis C virus (HCV) infection. The aim of this study was to determine the association between the genetic polymorphisms of Methods: In this case-control study, four single nucleotide polymorphisms (SNPs) of Results: After logistic regression analysis, the rs35440472-A and rs1130838-A alleles were found to be associated with a significantly elevated risk of HCV infection (OR = 1.562, 95% CI: 1.229-1.987, Conclusion:

Indexed as

AdultAllelesCase-Control StudiesChinaFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHepacivirusHepatitis CHLA-C AntigensHumansMaleMiddle AgedPolymorphism, Single NucleotideReceptors, KIRHLA-C AntigensReceptors, KIRhepatitis C virushuman leukocyte antigeninfectionkiller cell immunoglobulin-like receptorspolymorphism

Identifiers

PMID34220799
PMCPMC8253047
OpenAlexW3176562943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.