Evidence map›Paper›PMID 34220793›Full record

ArticleFrontiers in immunology2021

IL-4-Responsive B Cells Are Detrimental During Chronic Tuberculosis Infection in Mice.

Suraj P Parihar, Mumin Ozturk, Maxine A Höft, Julius E Chia, Reto Guler, Roanne Keeton, Ilana C van Rensburg, Andre G Loxton, Frank Brombacher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Dual oxidase 1 is dispensable duringFrontiers in immunology · 2023
    Article
  7. Cytokine Receptors-Regulators of Antimycobacterial Immune Response.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Suraj P PariharInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Mumin OzturkInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Maxine A HöftAFGrica Medical Mycology Research Unit, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Julius E ChiaInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Reto GulerInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Roanne KeetonDivision of Medical Virology, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Ilana C van RensburgDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Andre G LoxtonDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Frank BrombacherInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
University of Cape Town · ZASouth African Medical Research Council · ZAWellcome Centre for Infectious Diseases Research in Africa · ZAInternational Centre for Genetic Engineering and Biotechnology · ZAStellenbosch University · ZA

Funding

Medical Research Council MR/P028071/1Wellcome Trust 203135/Z/16/Z
6 · The paper itself

Abstract

In tuberculosis, T cell-mediated immunity is extensively studied whilst B cells received limited attention in human and mice. Of interest,

Indexed as

AnimalsB-LymphocytesChronic DiseaseCytokinesDisease Models, AnimalHumansImmunoglobulin AInflammation MediatorsInterleukin-4Interleukin-4 Receptor alpha SubunitLungMacrophagesMiceMice, Inbred BALB CMice, KnockoutMycobacterium tuberculosisCytokinesIl4ra protein, mouseImmunoglobulin AInflammation MediatorsInterleukin-4Interleukin-4 Receptor alpha SubunitReceptors, Cell SurfaceB cellshumanIL-4RAMice (balb/c)TB

Identifiers

PMID34220793
PMCPMC8243286
OpenAlexW3170226894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.