Evidence map›Paper›PMID 34220722›Full record

ReviewFrontiers in endocrinology2021

Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review.

Melissa L Kozakiewicz, Chad A Grotegut, Allyn C Howlett

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The impact of cannabinoids on reproductive function.Reproduction (Cambridge, England) · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Longitudinal course of endocannabinoids andPsychological medicine · 2023
    Article
  15. Cannabis and Paternal Epigenetic Inheritance.International journal of environmental research and public health · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Melissa L KozakiewiczDepartment of Obstetrics and Gynecology, Section on Maternal-Fetal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Chad A GrotegutDepartment of Obstetrics and Gynecology, Section on Maternal-Fetal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Allyn C HowlettDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Wake Forest University · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Cannabinoid Receptors and Associated Proteins-RenewalR01DA042157 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLYN C HOWLETT, W TODD LOWTHER · 2017 to 2026
$5.4M
The Role of Calcium Homeostasis in Regulating Uterine Contractility and ToneR01HD096385 · NICHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROTEGUT, CHAD A, ROSENBERG, PAUL B · 2019 to 2023
$2.7M
NCATS NIH HHS UL1 TR001420NICHD NIH HHS R01 HD096385NIDA NIH HHS R01 DA042157
6 · The paper itself

Abstract

The endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of sustaining the microenvironment necessary for early pregnancy success and maintenance. It plays a significant role in embryo development, transport and implantation as well as placentation. The current theory behind the initiation of term labor is that it is a complex, multifactorial process involving sex steroid hormones, prostaglandin production and interplay at the maternal-fetal interface resulting in increased expression of receptors and gap junctions that promote uterine activation. There is increasing evidence that, in addition to early pregnancy events, the ECS plays a regulatory role in pregnancy maintenance and the timing of labor. This review presents an overview of the ECS in pregnancy that focuses on late gestation and parturition.

Indexed as

Embryo ImplantationEmbryonic DevelopmentPregnancy MaintenanceAnimalsEndocannabinoidsFemaleHumansPregnancyUterusEndocannabinoidsanandamidecannabinoid receptorendocannabinoid systemlabormyometriumparturitionpregnancypreterm labor

Identifiers

PMID34220722
PMCPMC8242576
OpenAlexW3169190688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.