ArticleFrontiers in physiology2021
On the Optimization of a Centrifugal Maglev Blood Pump Through Design Variations.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Clinical evaluation of SafeCECThe journal of extra-corporeal technology · 2025Trial
- Shaping the Flow: Impact of Blade Shape on Performance and Hemocompatibility in Rotodynamic Blood Pumps.Artificial organs · 2026Article
- Hematologic complications and design challenges in cardiovascular devices.Communications engineering · 2026Review
- [Design of a benchmark pump model and optimization of hemolysis testing protocol for evaluation of blood pump hemocompatibility].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Optimized FDA Blood Pump: A Case Study in System-Level Customized Ventricular Assist Device Designs.Annals of biomedical engineering · 2025Article
- Article
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- Optimization of secondary flow path clearance in centrifugal blood pump: a combined numerical and experimental study.Frontiers in physiology · 2025Article
- Numerical investigation of flow characteristics in the front and rear chambers of centrifugal pump and pump as turbine.Scientific reports · 2024Article
- Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3.Biomechanics and modeling in mechanobiology · 2023Article
- Influence of Inlet Boundary Conditions on the Prediction of Flow Field and Hemolysis in Blood Pumps Using Large-Eddy Simulation.Bioengineering (Basel, Switzerland) · 2023Article
- Editorial: Recent advances in the design and preclinical evaluation of ventricular assist devices.Frontiers in physiology · 2023Article
- Numerical hemolysis performance evaluation of a rotary blood pump under different speed modulation profiles.Frontiers in physiology · 2023Article
- A novel model for hemolysis estimation in rotating impeller blood pumps considering red blood cell aging.Frontiers in physiology · 2023Article
- A comprehensive comparison of theFrontiers in physiology · 2023Article
- Optimization of a tri-drug treatment against lung cancer using orthogonal design in preclinical studies.PeerJ · 2023Article
- The Impact of a New Arterial Intravascular Pump on Aorta Hemodynamic Surrounding: A Numerical Study.Bioengineering (Basel, Switzerland) · 2022Article
- A Hemodynamic Analysis of the Thrombosis Within Occluded Coronary Arterial Fistulas With Terminal Aneurysms Using a Blood Stasis Model.Frontiers in physiology · 2022Article
- Flow characteristics and hemolytic performance of the new Breethe centrifugal blood pump in comparison with the CentriMag and Rotaflow pumps.The International journal of artificial organs · 2021Article
- The Design and Evaluation of a Portable Extracorporeal Centrifugal Blood Pump.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centrifugal blood pumps are usually designed with secondary flow paths to avoid flow dead zones and reduce the risk of thrombosis. Due to the secondary flow path, the intensity of secondary flows and turbulence in centrifugal blood pumps is generally very high. Conventional design theory is no longer applicable to centrifugal blood pumps with a secondary flow path. Empirical relationships between design variables and performance metrics generally do not exist for this type of blood pump. To date, little scientific study has been published concerning optimization and experimental validation of centrifugal blood pumps with secondary flow paths. Moreover, current hemolysis models are inadequate in an accurate prediction of hemolysis in turbulence. The purpose of this study is to optimize the hydraulic and hemolytic performance of an inhouse centrifugal maglev blood pump with a secondary flow path through variation of major design variables, with a focus on bringing down intensity of turbulence and secondary flows. Starting from a baseline design, through changing design variables such as blade angles, blade thickness, and position of splitter blades. Turbulent intensities have been greatly reduced, the hydraulic and hemolytic performance of the pump model was considerably improved. Computational fluid dynamics (CFD) combined with hemolysis models were mainly used for the evaluation of pump performance. A hydraulic test was conducted to validate the CFD regarding the hydraulic performance. Collectively, these results shed light on the impact of major design variables on the performance of modern centrifugal blood pumps with a secondary flow path.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.