Evidence map›Paper›PMID 34220464›Full record

ArticleFrontiers in behavioral neuroscience2021

Rest Is Required to Learn an Appetitively-Reinforced Operant Task in

Timothy D Wiggin, Yungyi Hsiao, Jeffrey B Liu, Robert Huber, Leslie C Griffith

Abstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Future avenues inLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  4. Reward expectations direct learning and drive operant matching inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Sleep benefits different stages of memory inFrontiers in physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Timothy D WigginDepartment of Biology, National Center for Behavioral Genomics and Volen Center for Complex Systems, Brandeis University, Waltham, MA, United States.
Yungyi HsiaoDepartment of Biology, National Center for Behavioral Genomics and Volen Center for Complex Systems, Brandeis University, Waltham, MA, United States.
Jeffrey B LiuDepartment of Biology, National Center for Behavioral Genomics and Volen Center for Complex Systems, Brandeis University, Waltham, MA, United States.
Robert HuberRadcliffe Institute for Advanced Studies, Harvard University, Cambridge, MA, United States.
Leslie C GriffithDepartment of Biology, National Center for Behavioral Genomics and Volen Center for Complex Systems, Brandeis University, Waltham, MA, United States.

Funding

Regulation of Intrinsic Plasticity in Neural CircuitsR01MH067284 · NIMH · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 2003 to 2025
$8.8M
Undergraduate and Graduate Training in Computational Neuroscience R90DA033463 · NIDA · BRANDEIS UNIVERSITY · PI MILLER, PAUL · 2011 to 2020
$2.0M
Synapses Between Dorsal Paired Medial (DPM) and Dopamine Neurons Modulate Sleep and Learning in DrosophilaF32NS098624 · NINDS · BRANDEIS UNIVERSITY · PI WIGGIN, TIMOTHY DAVID · 2016 to 2017
$113k
NIDA NIH HHS R90 DA033463NIMH NIH HHS R01 MH067284NINDS NIH HHS F32 NS098624
6 · The paper itself

Abstract

Maladaptive operant conditioning contributes to development of neuropsychiatric disorders. Candidate genes have been identified that contribute to this maladaptive plasticity, but the neural basis of operant conditioning in genetic model organisms remains poorly understood. The fruit fly

Indexed as

Drosophila melanogasteroperant conditioningoptogenetic activationrestsucrose reinforcementvideo tracking

Identifiers

PMID34220464
PMCPMC8250850

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.