ArticleFrontiers in neuroscience2021
Changes of Regional Neural Activity Homogeneity in Preclinical Alzheimer's Disease: Compensation and Dysfunction.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Convergent functional changes of the episodic memory impairment in mild cognitive impairment: An ALE meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- An Activation Likelihood Estimation Meta-Analysis of Specific Functional Alterations in Dorsal Attention Network in Mild Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Automatic identification of different stage of Alzheimer's disease using multimodal MRI and artificial intelligence.BMC medical imaging · 2026Article
- Quantitative EEG signatures of power and functional connectivity alterations in Alzheimer's disease and frontotemporal dementia.Scientific reports · 2026Article
- Association of functional brain alterations with β-amyloid, tau, and cognitive decline in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Individualized prediction of transition from subjective cognitive decline to mild cognitive impairment based on multimodal MRI: a 10-year follow-up study.The journal of prevention of Alzheimer's disease · 2026Article
- Regional homogeneity differences in resting-state fMRI between Parkinson's disease and multiple system atrophy-parkinsonian type.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- An exploratory study of altered regional homogeneity in Parkinson's disease with depression.Frontiers in psychiatry · 2026Article
- Memory Test Performance of People with Subjective Cognitive Decline Recruited From Different Settings: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Review
- Prediction Model and Nomogram for Amyloid Positivity Using Clinical and MRI Features in Individuals With Subjective Cognitive Decline.Human brain mapping · 2025Article
- Basal forebrain global functional connectivity is preserved in asymptomatic presenilin-1 E280A mutation carriers: Results from the Colombia cohort.The journal of prevention of Alzheimer's disease · 2025Article
- Research on magnetic resonance imaging in diagnosis of Alzheimer's disease.European journal of medical research · 2024Review
- Automatic detection of Alzheimer's disease from EEG signals using an improved AFS-GA hybrid algorithm.Cognitive neurodynamics · 2024Article
- Consensus on rapid screening for prodromal Alzheimer's disease in China.General psychiatry · 2024Review
- Brain amyloid-β deposition associated functional connectivity changes of ultra-large structural scale in mild cognitive impairment.Brain imaging and behavior · 2023Article
- Uncovering mnestic problems in help-seeking individuals reporting subjective cognitive complaints.Scientific reports · 2023Article
- Alterations in regional homogeneity and functional connectivity associated with cognitive impairment in patients with hypertension: a resting-state functional magnetic resonance imaging study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Mapping the long-term delayed recall-based cortex-hippocampus network constrained by the structural and functional connectome: a case-control multimodal MRI study.Alzheimer's research & therapy · 2023Article
- Alterations in degree centrality and cognitive function in breast cancer patients after chemotherapy.Brain imaging and behavior · 2022Article
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6 authors at 3 institutions in 1 country.
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Abstract
introductionSubjective cognitive decline (SCD) is the preclinical stage of Alzheimer's disease and may develop into amnestic mild cognitive impairment (aMCI). Finding suitable biomarkers is the key to accurately identifying SCD. Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies on SCD patients showed functional connectivity disorders. Our goal was to explore whether local neurological homogeneity changes in SCD patients, the relationship between these changes and cognitive function, and similarities of neurological homogeneity changes between SCD and aMCI patients. MATERIALS AND
methods37 cases of the healthy control (HC) group, 39 cases of the SCD group, and 28 cases of the aMCI group were included. Participants underwent rs-fMRI examination and a set of neuropsychological test batteries. Regional homogeneity (ReHo) was calculated and compared between groups. ReHo values were extracted from meaningful regions in the SCD group, and the correlation between ReHo values with the performance of neuropsychological tests was analyzed.
resultsOur results showed significant changes in the ReHo among groups. In the SCD group compared with the HC group, part of the parietal lobe, frontal lobe, and occipital lobe showed decreased ReHo, and the temporal lobe, part of the parietal lobe and the frontal lobe showed increased ReHo. The increased area of ReHo was negatively correlated with the decreased area, and was related to decrease on multiple neuropsychological tests performance. Simultaneously, the changed areas of ReHo in SCD patients are similar to aMCI patients, while aMCI group's neuropsychological test performance was significantly lower than that of the SCD group.
conclusionThere are significant changes in local neurological homogeneity in SCD patients, and related to the decline of cognitive function. The increase of neurological homogeneity in the temporal lobe and adjacent area is negatively correlated with cognitive function, reflecting compensation for local neural damage. These changes in local neurological homogeneity in SCD patients are similar to aMCI patients, suggesting similar neuropathy in these two stages. However, the aMCI group's cognitive function was significantly worse than that of the SCD group, suggesting that this compensation is limited. In summary, regional neural activity homogeneity may be a potential biomarker for identifying SCD and measuring the disease severity.
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