Evidence map›Paper›PMID 34220340›Full record

ArticleScience and technology of advanced materials2021

A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy.

Nanami Fujisawa, Masato Takanohashi, Lili Chen, Koichiro Uto, Yoshitaka Matsumoto, Masayuki Takeuchi, Mitsuhiro Ebara

Abstract read
In one paragraph

Article in Science and technology of advanced materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nanami FujisawaResearch Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan.ORCID https://orcid.org/0000-0002-8894-1790
Masato TakanohashiResearch Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan.
Lili ChenResearch Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan.ORCID https://orcid.org/0000-0001-8290-5230
Koichiro UtoResearch Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan.ORCID https://orcid.org/0000-0001-7091-0585
Yoshitaka MatsumotoDepartment of Radiation Oncology, University of Tsukuba Hospital, Tsukuba, Japan.ORCID https://orcid.org/0000-0002-2074-3042
Masayuki TakeuchiResearch Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan.ORCID https://orcid.org/0000-0002-0207-0665
Mitsuhiro EbaraResearch Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Japan.ORCID https://orcid.org/0000-0002-7906-0350

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reports a novel thermally enhanced drug release system synthesized via a dynamic Diels-Alder (DA) reaction to develop chemotherapy for pancreatic cancer. The anticancer prodrug was designed by tethering gemcitabine (GEM) to poly(furfuryl methacrylate) (PFMA) via

Indexed as

30 Bio-inspired and biomedical materials; 211 Scaffold/Tissue engineering/Drug deliveryalternating magnetic fieldcancerchemotherapyDiels-alder reactiongemcitabinelocal drug delivery

Identifiers

PMID34220340
PMCPMC8231351

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.