Evidence map›Paper›PMID 34220337›Full record

ReviewMediators of inflammation2021

Exploring the Crosstalk between Inflammation and Epithelial-Mesenchymal Transition in Cancer.

Indranil Chattopadhyay, Rangarao Ambati, Rohit Gundamaraju

Open access · goldAbstract readReview
In one paragraph

Review in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Antioxidants (Basel, Switzerland) · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Role ofCancer pathogenesis and therapy · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Multi-Target Protective Effects ofInternational journal of molecular sciences · 2025
    Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Indranil ChattopadhyayDepartment of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, India.
Rangarao AmbatiDepartment of Biotechnology, Vignan's Foundation for Science, Technology and Research Deemed to Be University, Vadlamudi, Di-522 213 Guntur, Andhra Pradesh, India.
Rohit GundamarajuER Stress and Mucosal Immunology Lab, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.ORCID https://orcid.org/0000-0001-5875-3003
Central University of Tamil Nadu · INUniversity of Tasmania · AUVignan's Foundation for Science, Technology & Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor cells undergo invasion and metastasis through epithelial-to-mesenchymal cell transition (EMT) by activation of alterations in extracellular matrix (ECM) protein-encoding genes, enzymes responsible for the breakdown of ECM, and activation of genes that drive the transformation of the epithelial cell to the mesenchymal type. Inflammatory cytokines such as TGF

Indexed as

Epithelial-Mesenchymal TransitionInflammationCadherinsCell Line, TumorCytokinesDisease ProgressionDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansInterleukin-1betaInterleukin-6NeoplasmsNeoplastic Stem CellsNeovascularization, PathologicSignal TransductionTransforming Growth Factor betaCadherinsCytokinesInterleukin-1betaInterleukin-6Transforming Growth Factor betaTumor Necrosis Factor-alpha

Identifiers

PMID34220337
PMCPMC8219436
OpenAlexW3167994896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.