ArticleOral science international2020
Role of osteoclasts in oral homeostasis and jawbone diseases.
Article in Oral science international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Histological findings in post-extraction sockets after alveolar ridge preservation with leukocyte- and platelet-rich fibrin: a randomized clinical trial.Journal of applied oral science : revista FOB · 2026Trial
- Impact of Osteoporosis on Dental Implant Survival, Failure, and Marginal Bone Loss: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine.Journal of advanced research · 2025Review
- Engineered Metal-Organic Frameworks for Targeted CRISPR/Cas9 Gene Editing.ACS pharmacology & translational science · 2025Review
- Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Navigating oxidative stress in oral bone regeneration: mechanisms and reactive oxygen species-regulating biomaterial strategies.Regenerative biomaterials · 2025Review
- Influence of bone morphogenetic protein (BMP) signaling and masticatory load on morphological alterations of the mouse mandible during postnatal development.Archives of oral biology · 2025Article
- Menopause-related changes to maxillary trabecular bone micro-architecture.Frontiers in aging · 2025Article
- Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- The effect of low-level laser therapy on osteoclast differentiation: Clinical implications for tooth movement and bone density.Journal of dental sciences · 2024Article
- Menopause-Associated Changes in Mandibular Bone Microarchitecture Are Site-Specific.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2024Article
- Article
- Advanced Hydrogel systems for mandibular reconstruction.Bioactive materials · 2023Review
- Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review.Current issues in molecular biology · 2023Review
- Effect ofNutrients · 2022Article
- Roles of osteoclasts in alveolar bone remodeling.Genesis (New York, N.Y. : 2000) · 2022Review
- Rubbing-Assisted Approach for Fabricating Oriented Nanobiomaterials.Micromachines · 2022Review
- The Therapeutic Potential of Secreted Factors from Dental Pulp Stem Cells for Various Diseases.Biomedicines · 2022Review
- Acvr1 deletion in osteoblasts impaired mandibular bone mass through compromised osteoblast differentiation and enhanced sRANKL-induced osteoclastogenesis.Journal of cellular physiology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The jawbone is a unique structure as it serves multiple functions in mastication. Given the fact that the jawbone is remodeled faster than other skeletal bones, bone cells in the jawbone may respond differently to local and systemic cues to regulate bone remodeling and adaptation. Osteoclasts are bone cells responsible for removing old bone, playing an essential role in bone remodeling. Although bone resorption by osteoclasts is required for dental tissue development, homeostasis and repair, excessive osteoclast activity is associated with oral skeletal diseases such as periodontitis. In addition, antiresorptive medications used to prevent bone homeostasis of tumors can cause osteonecrosis of the jaws that is a major concern to the dentist. Therefore, understanding of the role of osteoclasts in oral homeostasis under physiological and pathological conditions leads to better targeted therapeutic options for skeletal diseases to maintain patients' oral health. Here, we highlight the unique features of the jawbone compared to the long bone and the involvement of osteoclasts in the jawbone-specific diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.