Evidence map›Paper›PMID 34220264›Full record

ArticleSaudi journal of biological sciences2021

Anti-obesity potential of almond (Prunus dulcis) in experimental animals under cafeteria and atherogenic diets.

Syed Mohammed Basheeruddin Asdaq, Shrey Tambe, Yahya Mohzari, Ahmed Alrashed, Hamdan Najib Alajami, Awad Othman Aljohani, Abdullah Ali Al Mushtawi, Majed Sultan Alenazy, Rakan Fahad Alamer, Abdulmajead Khalid Alanazi and 1 more

Abstract read
In one paragraph

Article in Saudi journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Syed Mohammed Basheeruddin AsdaqDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, 13713 Riyadh, Saudi Arabia.
Shrey TambeDepartment of Pharmacology, Krupanidhi College of Pharmacy, Bangalore 560035, India.
Yahya MohzariClinical Pharmacy Department, King Saud Medical City, Riyadh 12746, Saudi Arabia.
Ahmed AlrashedPharmaceutical Services Administration, Inpatient Department, Main Hospital, KFMC, Riyadh 11564, Saudi Arabia.
Hamdan Najib AlajamiPharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia.
Awad Othman AljohaniPharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia.
Abdullah Ali Al MushtawiPharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia.
Majed Sultan AlenazyPharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia.
Rakan Fahad AlamerPharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia.
Abdulmajead Khalid AlanaziPharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia.
Syed Imam RabbaniDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesNatural dietary supplements are progressively getting famous to supplant synthetic substances particularly in chronic morbidities. The aim of this study was to evaluate the anti-obesity potential of almond on the normal, Cafeteria, and Atherogenic diets. MATERIALS AND

methodsParameters such as change in body weight, body temperature, lipid profile, organ weights, and fat pad weights were assessed. Central Nervous System related studies (Despair Swim test and Elevated Plus maze test) were also performed to comprehend the effect of the diets, and almond on the brain. All of the experimental animals were randomly assigned to one of three diet categoriesregular, cafeteria, or atherogenic, and fed those diets for 40 days. Each diet had the control group, standard drug group and three almond groups (low dose: 50; medium dose: 100 and high dose: 200 mg/kg body weight). Body weight was recorded every alternate day. On 40th day, body temperature was measured. On day 41, lipid parameters, organ weights, fat pad weights and the CNS parameters were evaluated. ANOVA followed by Duncans Multiple Range Test were used for statistical analysis.

resultsTreatment of animals with either a low or high dose of almond as well as a standard herb prevented a rise in body weight significantly (p = 0.01) in all three diet groups. When a regular diet was replaced with a cafeteria and atherogenic diet, the serum levels of triglycerides and LDL increased significantly, while HDL levels decreased significantly. Overall, almond preparation reduced lipid parameters, organ weights, fat-pad weights, and stabilized CNS parameters substantially. INTERPRETATION &

conclusionThe almond high dose was the most effective of all the almond preparations. Our study suggests that chronic administration of almond independently reduces the body weight in experimental animals.

Indexed as

AlmondAtherogenic dietCafeteria dietCNS parametersLipid parametersObesity

Identifiers

PMID34220264
PMCPMC8241617

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.