Functional analysis of deleterious

Dan Li, Xiaoyan Han, Zhennan Zhao, Yi Lu, Jin Yang

Open access · greenAbstract read

In one paragraph

Article in Molecular vision, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.2field-weighted citation impact, top 45% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

Canonical ligand-dependent and non-canonical ligand-independent EphA2 signaling in the eye lens of wild-type, knockout, and aging mice.Aging · 2024
Article
Roles of Eph-Ephrin Signaling in the Eye Lens Cataractogenesis, Biomechanics, and Homeostasis.Frontiers in cell and developmental biology · 2022
Review
Structural and functional analysis of SNP rs76740365 G>A in exon-3 of the alpha A-crystallin gene in lens epithelial cells.Molecular vision · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dan LiEye Institute, Eye & ENT Hospital of Fudan University, Shanghai, China.

Xiaoyan HanEye Institute, Eye & ENT Hospital of Fudan University, Shanghai, China.

Zhennan ZhaoEye Institute, Eye & ENT Hospital of Fudan University, Shanghai, China.

Yi LuEye Institute, Eye & ENT Hospital of Fudan University, Shanghai, China.

Jin YangEye Institute, Eye & ENT Hospital of Fudan University, Shanghai, China.

Eye & ENT Hospital of Fudan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Ephrin (Eph) receptor A2 ( Methods: The four Results: Compared with the WT and the other three mutations, the rs137853199 mutation specifically resulted in a significant decrease in the expression of EPHA2. We identified that EPHA2 rs137853199 is degraded via the ubiquitin-proteasomal pathway through a lysine-48 (K48) residue linkage. Furthermore, the knockdown of Conclusions: In summary, these findings suggest a mechanism by which a point mutation in

Indexed as

AgedAged, 80 and overBlotting, WesternCataractEpithelial CellsFemaleGene Expression RegulationHumansLens, CrystallineLentivirusMaleMiddle AgedPoint MutationPolymorphism, Single NucleotideReal-Time Polymerase Chain ReactionReceptor, EphA2EPHA2 protein, humanReceptor, EphA2

Identifiers

PMID34220184

PMCPMC8219505

OpenAlexW4287481740

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.