Evidence map›Paper›PMID 34220123›Full record

ArticleVeterinary world2021

Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study.

Luiz Eduardo Rodrigues, Milena Miyoshi Kishibe, Rogeria Keller, Heliard Rodrigues Dos Santos Caetano, Marcos Natal Rufino, Osimar de Carvalho Sanches, Ines Cristina Giometti, Rogério Giuffrida, Hermann Bremer-Neto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary world, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luiz Eduardo RodriguesDepartment of Functional Sciences, Laboratory of Physiology and Biophysics, Faculty of Medicine, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.
Milena Miyoshi KishibeDepartment of Functional Sciences, Laboratory of Physiology and Biophysics, Faculty of Medicine, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.
Rogeria KellerDepartment of Functional Sciences, Laboratory of Microbiology, Faculty of Biological Sciences, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.
Heliard Rodrigues Dos Santos CaetanoDepartment of Functional Sciences, Laboratory of Physiology, Faculty of Physiotherapy, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.
Marcos Natal RufinoDepartment of Functional Sciences, Laboratory of Physiology, Faculty of Medicine, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.
Osimar de Carvalho SanchesDepartment of Pathology, Faculty of Veterinary Medicine, Universidade de Santo Amaro, São Paulo, Brazil.
Ines Cristina GiomettiDepartment of Reproduction, Faculty of Veterinary Medicine, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.
Rogério GiuffridaDepartment of Statistics, Faculty of Veterinary Medicine, Universidade do Oeste Paulista, São Paulo, Brazil.
Hermann Bremer-NetoDepartment of Functional Sciences, Laboratory of Physiology and Biophysics, Faculty of Medicine, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.
Universidade do Oeste Paulista · BRUniversidade de Santo Amaro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the brain-intestinal axis, including maintaining male reproductive function and spermatogenesis and regulating stress. The aim of the present study was to evaluate the action of MOS on testosterone and corticosterone concentrations and the reproductive system development of rats in the growth phase as an animal model. MATERIALS AND

methodsIn total, 128 male rats were used, randomly divided into four experimental groups (n=32): Control; MOS 1; MOS 2; and MOS 3. From each group, eight animals were sacrificed in four experimental moments (14, 28, 42, and 56 days, respectively, moments 1, 2, 3, and 4) and hormonal measurements and histological evaluations were performed.

resultsThe results revealed the effect of diet, MOS, and timing on testicle weight (p<0.05). At moments 3 and 4, the groups supplemented with MOS showed higher concentrations of testosterone and decreased corticosterone levels throughout the experimental period. Groups supplemented with MOS showed an increase in the frequency of relative sperm and sperm scores. The radii of the seminiferous tubules presented a significant statistical effect of the diet, moments, and diet + moment interaction.

conclusionIt was concluded that the three different MOS prebiotics brought forward sexual maturity.

Indexed as

corticosteronemurineprebioticreproductive systemtestosteroneyeast

Identifiers

PMID34220123
PMCPMC8243662
OpenAlexW3165500006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.