Evidence map›Paper›PMID 34219865›Full record

ArticleBiocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al2021

Visualization of integrin molecules by fluorescence imaging and techniques.

Chen Cai, Hao Sun, Liang Hu, Zhichao Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. FRET Visualization of Cyclic Stretch-Activated ERKFrontiers in cell and developmental biology · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chen CaiDepartment of Immunology, School of Medicine, UConn Health, Farmington, 06030, USA.
Hao SunDepartment of Medicine, University of California, San Diego, La Jolla, 92093, USA.
Liang HuCardiovascular Institute of Zhengzhou University, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450051, China.
Zhichao FanDepartment of Immunology, School of Medicine, UConn Health, Farmington, 06030, USA.

Funding

Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammationR01HL145454 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI FAN, ZHICHAO · 2019 to 2023
$2.1M
NHLBI NIH HHS R01 HL145454
6 · The paper itself

Abstract

Integrin molecules are transmembrane αβ heterodimers involved in cell adhesion, trafficking, and signaling. Upon activation, integrins undergo dynamic conformational changes that regulate their affinity to ligands. The physiological functions and activation mechanisms of integrins have been heavily discussed in previous studies and reviews, but the fluorescence imaging techniques -which are powerful tools for biological studies- have not. Here we review the fluorescence labeling methods, imaging techniques, as well as Förster resonance energy transfer assays used to study integrin expression, localization, activation, and functions.

Indexed as

Fluorescence imagingFluorescence labelingFRETIntegrinsIntravital imagingLive-cell imagingSuper-resolution imaging

Identifiers

PMID34219865
PMCPMC8249084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.