ArticleAphasiology2021
Primary Progressive Apraxia of Speech: From Recognition to Diagnosis and Care.
Article in Aphasiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Behavioral Treatment for Speech and Language in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech: A Systematic Review.Neuropsychology review · 2024Pooled it
- Dyslexia and dysgraphia of primary progressive aphasia in Chinese: A systematic review.Frontiers in neurology · 2022Pooled it
- Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.Translational psychiatry · 2024Trial
- Deep learning-derived measures of sound-level accuracy in primary progressive apraxia of speech: A feasibility pipeline with descriptive evidence from two cases.Clinical linguistics & phonetics · 2026Article
- Voice and Speech in Atypical Parkinsonian Disorders.Movement disorders clinical practice · 2026Review
- Diagnosing Apraxia of Speech in Children and Adults When There Is No Gold Standard: A Scoping Review About the Diagnostic Process.American journal of speech-language pathology · 2026Article
- Neural and Behavioral Predictors of Speech Motor Sequence Learning in Primary Progressive Aphasia.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Telephone-based cognitive screening in neurodegenerative MCI and dementia: preliminary findings from the TBCS Study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Clinicopathological and Neuroimaging Correlates of Disease Duration in Primary Progressive Apraxia of Speech.European journal of neurology · 2025Article
- Uncovering Image-Driven Subtypes with Distinct Pathology and Clinical Course in Autopsy-Confirmed Four Repeat Tauopathies.Annals of neurology · 2025Article
- Pick's disease presenting as progressive apraxia of speech: Atypical clinical and neuroimaging features in three autopsy-confirmed cases.Clinical neurology and neurosurgery · 2025Article
- Distinct 11C-ER176 PET Neuroinflammatory Profiles and Tau Colocalization in Progressive Apraxia of Speech With and Without Parkinson-plus Syndrome.Clinical nuclear medicine · 2025Article
- Psycholinguistic Variables and Spelling Accuracy for People with Logopenic Variant Primary Progressive Aphasia: A Cross-Sectional Study.Aphasiology · 2025Article
- Brain Cortical Volume and Thickness Abnormalities in Autism Spectrum Disorder Aged 2-4 Years: a Structural MRI Comparative Study.Journal of autism and developmental disorders · 2025Article
- Dysphagia and Mortality Risk in Individuals With Primary Progressive Apraxia of Speech.Annals of clinical and translational neurology · 2025Article
- Unveiling the enigmatic: Primary progressive apraxia of speech - A case report.Clinical parkinsonism & related disorders · 2025Article
- Word Count Matters: Features of Written Language Production in Progressive Apraxia of Speech with and without Agrammatism.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2025Article
- High-definition brain stimulation targeting separate regions leads to differential word retrieval outcomes in patients with primary progressive aphasia: a pilot study.Frontiers in neurology · 2025Article
- Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundApraxia of speech (AOS) can be caused by neurodegenerative disease and sometimes is its presenting sign (i.e., primary progressive apraxia of speech, PPAOS). During the last several decades our understanding of PPAOS has evolved from clinical recognition to a fuller understanding of its core and associated clinical features, its distinction from but relationship with primary progressive aphasia, its temporal course and eventual progression to include other neurological deficits, and its neuroimaging correlates and underlying pathology.
aimsThis paper provides a comprehensive summary of the literature that has built the current knowledge base about PPAOS and progressive AOS as it co-occurs with progressive aphasia. It reviews the history of its emergence as a recognized syndrome; its relationship with the agrammatic/nonfluent variant of primary progressive aphasia; its salient perceptual features and subtypes; the acoustic and structural/physiological imaging measures that index its presence, severity, and distinction from aphasia; and principles and available data regarding its management and care. MAIN CONTRIBUTION: A broad summary of what is known about AOS as a manifestation of neurodegenerative disease.
conclusionsPrimary progressive apraxia of speech is a recognizable syndrome that can be distinguished from other neurodegenerative conditions that affect speech and language.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.