Evidence map›Paper›PMID 34219739›Full record

ArticleJournal of Alzheimer's disease : JAD2021

Normative References for Graphomotor and Latency Digital Clock Drawing Metrics for Adults Age 55 and Older: Operationalizing the Production of a Normal Appearing Clock.

Anis Davoudi, Catherine Dion, Erin Formanski, Brandon E Frank, Shawna Amini, Emily F Matusz, Victor Wasserman, Dana Penney, Randall Davis, Parisa Rashidi and 5 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The New Frontier of Perioperative Cognitive Medicine for Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Anis DavoudiDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Catherine DionClinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Erin FormanskiClinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Brandon E FrankClinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Shawna AminiDepartment of Anesthesiology, University of Florida, Gainesville, FL, USA.
Emily F MatuszDepartment of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, School of Osteopathic Medicine, Rowan University, NJ, USA.
Victor WassermanDepartment of Psychology, Rowan University, NJ, USA.
Dana PenneyDepartment of Neurology, Lahey Clinic Medical Center, Burlington, MA, USA.
Randall DavisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Parisa RashidiDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Patrick J TigheDepartment of Anesthesiology, University of Florida, Gainesville, FL, USA.
Kenneth M HeilmanDepartment of Neurology, Veterans Affairs Medical Center, University of Florida, Gainesville, FL, USA.
Rhoda AuFramingham Heart Study, Boston University School of Medicine, Boston, MA, USA.
David J LibonDepartment of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, School of Osteopathic Medicine, Rowan University, NJ, USA.
Catherine C PriceClinical and Health Psychology, University of Florida, Gainesville, FL, USA.
University of Florida · USUniversity of Florida Health · USRowan University · USFramingham Heart Study · USLahey Hospital and Medical Center · USMassachusetts Institute of Technology · US

Funding

EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
MRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young AdultsR01AG033040 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 2009 to 2019
$11.2M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive declineRF1AG054156 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, RYU, HOON · 2016 to 2018
$3.4M
PRECEDE: PREsurgical Cognitive Evaluation via Digital clockfacEdrawingR01AG055337 · NIA · UNIVERSITY OF FLORIDA · PI CATHERINE E PRICE, Parisa Rashidi · 2017 to 2026
$3.2M
White Matter Connectivity and PD Cognitive PhenotypesR01NS082386 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2013 to 2017
$2.3M
Neuroimaging Biomarkers for Post-Operative Cognitive Decline in Older AdultsR01NR014181 · NINR · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2012 to 2016
$2.3M
Cognitive Heterogeneity in those with high Alzheimer's Disease RiskRF1AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2020 to 2021
$1.8M
Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related DementiasK07AG066813 · NIA · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2020 to 2024
$810k
White Matter and Cognition in Parkinson's DiseaseK23NS060660 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2007 to 2011
$619k
Autonomous Pain Recognition in Non-Verbal and Critically Ill PatientsR21EB027344 · NIBIB · UNIVERSITY OF FLORIDA · PI RASHIDI, PARISA · 2019 to 2022
$577k
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NIA NIH HHS K07 AG066813NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG049810NIA NIH HHS R01 AG055337NIA NIH HHS R56 AG062109NIA NIH HHS RF1 AG054156NIA NIH HHS RF1 AG062109NIBIB NIH HHS R21 EB027344NINDS NIH HHS K23 NS060660NINDS NIH HHS R01 NS082386NINR NIH HHS R01 NR014181
6 · The paper itself

Abstract

backgroundRelative to the abundance of publications on dementia and clock drawing, there is limited literature operationalizing 'normal' clock production.

objectiveTo operationalize subtle behavioral patterns seen in normal digital clock drawing to command and copy conditions.

methodsFrom two research cohorts of cognitively-well participants age 55 plus who completed digital clock drawing to command and copy conditions (n = 430), we examined variables operationalizing clock face construction, digit placement, clock hand construction, and a variety of time-based, latency measures. Data are stratified by age, education, handedness, and number anchoring.

resultsNormative data are provided in supplementary tables. Typical errors reported in clock research with dementia were largely absent. Adults age 55 plus produce symmetric clock faces with one stroke, with minimal overshoot and digit misplacement, and hands with expected hour hand to minute hand ratio. Data suggest digitally acquired graphomotor and latency differences based on handedness, age, education, and anchoring.

conclusionData provide useful benchmarks from which to assess digital clock drawing performance in Alzheimer's disease and related dementias.

Indexed as

BenchmarkingNeuropsychological TestsAgedCognitionFemaleHumansMaleReaction TimeWritingagingattentionclock drawing testcognitiondementiadigital technologyexecutive functionlateralitymiddle agedneuropsychological testsOlder adultreference standardsshort-term memory

Identifiers

PMID34219739
PMCPMC8379638
OpenAlexW3175003843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.