ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2022
Reproducibility of quantitative flow ratio: the QREP study.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Beyond Angiography: Integrating Advanced Diagnostic Modalities in Coronary Stent Restenosis-a Systematic Review.International journal of medical sciences · 2026Pooled it
- Diagnostic accuracy of optical flow ratio: an individual patient-data meta-analysis.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Pooled it
- Quantitative flow ratio versus fractional flow reserve for Heart Team decision-making in multivessel disease: the randomised, multicentre DECISION QFR trial.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Trial
- VERMONT μQFR: Diagnostic Accuracy of Murray Law-Based 2D-μQFR Compared to 3D-μQFR and vFFR.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Validation of angiography-based FFR in non-culprit vessels of patients presenting with STEMI.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Experimental comparisons of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations.The international journal of cardiovascular imaging · 2026Article
- Angiography-Derived Physiology for Coronary Artery Disease Assessment: Expert Opinion From a SCAI Roundtable.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Review
- Diagnostic Performance of Angiography-Derived FFR According to the Analysis Factors.Korean circulation journal · 2026Article
- Stepwise Assessment of Computational Coronary Physiology and Plaque Vulnerability: Impact on Coronary Revascularization Decision Making.JACC. Asia · 2026Article
- "Vox Populi" Fractional Flow Reserve (vpFFR)-Leveraging Wisdom of the Crowd for the Assessment of Hemodynamic Severity of Intermediate Coronary Lesions.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasonic flow ratio versus Murray law-based quantitative flow ratio for predicting target vessel failure after IVUS-guided PCI.Frontiers in cardiovascular medicine · 2026Article
- Murray Law-Based Quantitative Flow Ratio Proficiency in Clinical Practice: Validating Routine Diagnostic Performance and Analyzing Learning Curve Thresholds.Journal of the American Heart Association · 2025Article
- Remote assessment of coronary stenosis - a valid alternative to invasive testing for non-culprit lesions?Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Real-World Comparison of FFR and QFR: New Perspectives on the Functional Assessment of Coronary Stenoses.Journal of clinical medicine · 2025Article
- Diagnostic performance of target vs. vessel μFR in stable coronary artery disease.BMC cardiovascular disorders · 2025Article
- The pressure wire holds its ground: the debacle of QFR.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Quantitative plaque characterization, pericoronary fat attenuation index, and fractional flow reserve: a novel method for differentiating between stable and unstable angina pectoris in a case-control study.Quantitative imaging in medicine and surgery · 2025Article
- Ultrasonic flow ratio measured immediately after successful rotational atherectomy with stent implantation predicts major adverse cardiovascular events.Frontiers in cardiovascular medicine · 2025Article
- Quantitative flow ratio will supplant wire-based physiological indices: pros and cons.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4).Heart (British Cardiac Society) · 2024Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuantitative flow ratio (QFR) is a tool for physiological lesion assessment based on invasive coronary angiography.
aimsWe aimed to assess the reproducibility of QFR computed from the same angiograms as assessed by multiple observers from different, international sites.
methodsWe included 50 patients previously enrolled in dedicated QFR studies. QFR was computed twice, one month apart by five blinded observers. The main analysis was the coefficient of variation (CV) as a measure of intra- and inter-observer reproducibility. Key secondary analysis was the identification of clinical and procedural characteristics predicting reproducibility.
resultsThe intra-observer CV ranged from 2.3% (1.5-2.8) to 10.2% (6.6-12.0) among the observers. The inter-observer CV was 9.4% (8.0-10.5). The QFR observer, low angiographic quality, and low fractional flow reserve (FFR) were independent predictors of a large absolute difference between repeated QFR measurements defined as a difference larger than the median difference (>0.03).
conclusionsThe inter- and intra-observer reproducibility for QFR computed from the same angiograms ranged from high to poor among multiple observers from different sites with an average agreement of 0.01±0.08 for repeated measurements. The reproducibility was dependent on the observer, angiographic quality and the coronary artery stenosis severity as assessed by FFR.
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