ArticleeLife2021
Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques.Neuroscience bulletin · 2026Article
- Cross-Species Cortical Geometry Reveals Conserved Gradients Across Primates and Human-Specific Expansion.bioRxiv : the preprint server for biology · 2025Article
- Hemispheric disconnection as a basis for neurodegeneration in apraxia and Alzheimer's disease.Discover mental health · 2025Review
- Shared and distinct alterations of thalamic subregional functional connectivity in early- and late-onset obsessive-compulsive disorder.Psychological medicine · 2025Article
- Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Chimpanzee Brainnetome Atlas reveals distinct connectivity and gene expression profiles relative to humans.Innovation (Cambridge (Mass.)) · 2025Article
- Article
- Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study.Nature and science of sleep · 2025Article
- Article
- Inhibition of the inferior parietal lobe triggers state-dependent network adaptations.Heliyon · 2024Article
- Comparative Analysis of Human-Chimpanzee Divergence in Brain Connectivity and its Genetic Correlates.bioRxiv : the preprint server for biology · 2024Article
- Evolutionary continuity and divergence of auditory dorsal and ventral pathways in primates revealed by ultra-high field diffusion MRI.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hemispheric coupling between structural and functional asymmetries in clinically asymptomatic carotid stenosis with cognitive impairment.Brain imaging and behavior · 2024Article
- Action observation reveals a network with divergent temporal and parietal cortex engagement in dogs compared with humans.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A revised perspective on the evolution of the lateral frontal cortex in primates.Science advances · 2023Article
- Pulvinar Response Profiles and Connectivity Patterns to Object Domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The parietal lobe evolution and the emergence of material culture in the human genus.Brain structure & function · 2023Review
- Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth.Biological psychiatry · 2022Article
- Neuroanatomical asymmetries in nonhuman primates in the homologs to Broca's and Wernicke's areas: a mini-review.Emerging topics in life sciences · 2022Article
- Brain intrinsic connection patterns underlying tool processing in human adults are present in neonates and not in macaques.NeuroImage · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The inferior parietal lobule (IPL) is one of the most expanded cortical regions in humans relative to other primates. It is also among the most structurally and functionally asymmetric regions in the human cerebral cortex. Whether the structural and connectional asymmetries of IPL subdivisions differ across primate species and how this relates to functional asymmetries remain unclear. We identified IPL subregions that exhibited positive allometric in both hemispheres, scaling across rhesus macaque monkeys, chimpanzees, and humans. The patterns of IPL subregions asymmetry were similar in chimpanzees and humans, but no IPL asymmetries were evident in macaques. Among the comparative sample of primates, humans showed the most widespread asymmetric connections in the frontal, parietal, and temporal cortices, constituting leftward asymmetric networks that may provide an anatomical basis for language and tool use. Unique human asymmetric connectivity between the IPL and primary motor cortex might be related to handedness. These findings suggest that structural and connectional asymmetries may underlie hemispheric specialization of the human brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.