ArticleJournal of the American Heart Association2021
Cardiovascular Biomarkers of Obesity and Overlap With Cardiometabolic Dysfunction.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Sex specific pattern of adipose expansion, inflammation and dysfunction with short term high fat diet exposure.Frontiers in endocrinology · 2026Article
- Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Development and Application of Children's Sex- and Age-Specific Fat-Mass and Muscle-Mass Reference Curves From Dual-Energy X-Ray Absorptiometry Data for Predicting Cardiometabolic Risk.Pediatric obesity · 2025Article
- Human plasma proteomic profile of clonal hematopoiesis.Nature communications · 2025Article
- Effect of Self-reported Physical Activity on Glycaemia and Blood Pressure in Healthy Participants from Bissau: A Cross-sectional Study.Sports medicine - open · 2025Article
- Associations of triglyceride-glucose index with N-terminal pro-B-type natriuretic peptide and mortality in middle-aged and elderly individuals.Frontiers in endocrinology · 2025Article
- Sex Differences in Protein Biomarkers and Measures of Fat Distribution.Journal of the American Heart Association · 2024Observational
- Cardiovascular Disease May Be Triggered by Gut Microbiota, Microbial Metabolites, Gut Wall Reactions, and Inflammation.International journal of molecular sciences · 2024Review
- Syn-COM: A Multi-Level Predictive Synergy Framework for Innovative Drug Combinations.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Matricellular proteins in immunometabolism and tissue homeostasis.BMB reports · 2024Review
- Human cord plasma proteomic analysis reveals sexually dimorphic proteins associated with intrauterine growth restriction.Proteomics · 2024Article
- A Mass Spectrometry-Based Proteome Study of Twin Pairs Discordant for Incident Acute Myocardial Infarction within Three Years after Blood Sampling Suggests Novel Biomarkers.International journal of molecular sciences · 2024Article
- Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Applicability of Diagnostic Criteria and High Prevalence of Familial Dysbetalipoproteinemia in Russia: A Pilot Study.International journal of molecular sciences · 2023Article
- A network medicine approach to study comorbidities in heart failure with preserved ejection fraction.BMC medicine · 2023Article
- Review
- Article
- Changes in body composition and subsequent cardiovascular disease risk among 5-year breast cancer survivors.Frontiers in cardiovascular medicine · 2023Article
- Nutritional supplements improve cardiovascular risk factors in overweight and obese patients: A Bayesian network meta-analysis.Frontiers in nutrition · 2023Article
- Associations between insulin-like growth factor binding protein-2 and lipoprotein kinetics in men.Journal of lipid research · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Background Obesity may be associated with a range of cardiometabolic manifestations. We hypothesized that proteomic profiling may provide insights into the biological pathways that contribute to various obesity-associated cardiometabolic traits. We sought to identify proteomic signatures of obesity and examine overlap with related cardiometabolic traits, including abdominal adiposity, insulin resistance, and adipose depots. Methods and Results We measured 71 circulating cardiovascular disease protein biomarkers in 6981 participants (54% women; mean age, 49 years). We examined the associations of obesity, computed tomography measures of adiposity, cardiometabolic traits, and incident metabolic syndrome with biomarkers using multivariable regression models. Of the 71 biomarkers examined, 45 were significantly associated with obesity, of which 32 were positively associated and 13 were negatively associated with obesity (false discovery rate
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.