ArticleMolecular plant pathology2021
The C5 protein encoded by Ageratum leaf curl Sichuan virus is a virulence factor and contributes to the virus infection.
Article in Molecular plant pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 44 citations in OpenAlex.
- SLCMV-Encoded BC1 Protein Suppresses Photosynthesis by Disrupting Chloroplast Structure and Gene Expression.Molecular plant pathology · 2026Article
- The Begomovirus Disease Tetrahedron: Weeds as the Missing Dimension in Virus Epidemiology.Viruses · 2026Review
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- Geminiviral replication enhancer hijacks a negative regulator of cytokinin signaling to facilitate viral infection.Plant communications · 2025Article
- A novel interspecific-recombinant monopartite begomovirus emerging in tomato (Solanum lycopersicum L.) genotypes with Ty-resistant genes.Molecular biology reports · 2025Article
- The Role of a C-Terminal Seven-Amino Acid Motif in TbCSV C3 Protein and Its Interaction With NbPOLA2 in Enhancing Viral Replication.Molecular plant pathology · 2025Article
- Wheat Yellow Mosaic Virus P1 Inhibits ROS Accumulation to Facilitate Viral Infection.International journal of molecular sciences · 2025Article
- In Silico Investigation of the Interactions Between Cotton Leaf Curl Multan Virus Proteins and the Transcriptional Gene Silencing Factors of Gossypium hirsutum L.Journal of molecular evolution · 2024Article
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- Research Progress on Viruses ofBiology · 2024Review
- Molecular characterization of begomovirus and DNA satellites associated with mosaic and leaf curl disease of Jamaica cherry (Virusdisease · 2024Article
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- A prophage-encoded nonclassical secretory protein of "Candidatus Liberibacter asiaticus" induces a strong immune response in Nicotiana benthamiana and citrus.Molecular plant pathology · 2022Article
- Role of Diversity and Recombination in the Emergence of Chilli Leaf Curl Virus.Pathogens (Basel, Switzerland) · 2022Article
- The novel C5 protein from tomato yellow leaf curl virus is a virulence factor and suppressor of gene silencing.Stress biology · 2022Article
- Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana.PLoS pathogens · 2022Article
- AC5 protein encoded by squash leaf curl China virus is an RNA silencing suppressor and a virulence determinant.Frontiers in microbiology · 2022Article
- The C5 protein encoded by Ageratum leaf curl Sichuan virus is a virulence factor and contributes to the virus infection.Molecular plant pathology · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Earlier reports have indicated that begomoviruses encode four proteins (AC1/C1, AC2/C2, AC3/C3, and AC4/C4 proteins) using complementary-sense DNA as the template. In recent years, several reports have shown that some begomoviruses also encode an AC5/C5 protein from the complementary DNA strand, and these AC5/C5 proteins play different roles in virus infections. Here, we provide evidence showing that Ageratum leaf curl Sichuan virus (ALCScV), a monopartite begomovirus, also encodes a C5 protein that is important for disease symptom formation and can affect viral replication. Infection of Nicotiana benthamiana plants with a potato virus X (PVX)-based vector carrying the ALCScV C5 gene resulted in more severe disease symptoms and higher virus accumulation levels. ALCScV C5 protein can be found in the cytoplasm and the nucleus. Furthermore, this protein is also a suppressor of posttranscriptional gene silencing. Mutational analysis showed that knockout of C5 gene expression significantly reduced ALCScV-induced disease symptoms and virus accumulation, while expression of the C5 gene using the PVX-based vector enhanced ALCScV accumulation in coinfected N. benthamiana plants.
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