ArticleAnnals of pediatric endocrinology & metabolism2021
Subclinical hypothyroidism in children: updates for pediatricians.
Article in Annals of pediatric endocrinology & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Bibliometric analysis of research on pediatric hypothyroidism treatment: a global perspective on trends and emerging fronts (2018-2026).Frontiers in pediatrics · 2026Pooled it
- Heterozygous TSHR Variants in Pediatric Idiopathic Subclinical Hypothyroidism: Association with a Variable and Compensated Thyroid PhenotypeJournal of clinical research in pediatric endocrinology · 2026Article
- Subclinical Hypothyroidism in Children: Natural History, Risk Factors, and OutcomesJournal of clinical research in pediatric endocrinology · 2026Article
- A review on levothyroxine therapy and bone age in children with long-standing untreated acquired hypothyroidism.Bioinformation · 2026Article
- Obesity-related subclinical hypothyroidism in childhood: Elevated triglycerides but not basal metabolic rate.Pediatric research · 2025Article
- Diagnosis of Thyroid Nodules in Children and Adolescents with Subclinical Hypothyroidism and Their Outcomes after Early Thyroxine Treatment-A Longitudinal Study.Diagnostics (Basel, Switzerland) · 2024Article
- Polyethylene glycol thyroid-stimulating hormone (PEG-TSH) testing in the management of pediatric thyroid dysfunction.Endocrine · 2024Observational
- Not Only Metabolic Complications of Childhood Obesity.Nutrients · 2024Review
- Effects of iodine status on thyroid volume and goiter in children living in an iodine-replete area.European thyroid journal · 2023Article
- Reference intervals for serum TSH concentrations of healthy children from the Central Region of Brazil.Archives of endocrinology and metabolism · 2023Article
- Relationship of iodine excess with thyroid function in 6-year-old children living in an iodine-replete area.Frontiers in endocrinology · 2023Article
- Potential Association between Subclinical Hypothyroidism and Childhood Migraine.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subclinical hypothyroidism (SH) is defined as serum thyroid-stimulating hormone (TSH) above the upper limit of the reference range in the presence of normal free T4 concentrations. Depending on the degree of TSH elevation, SH could be defined as mild (TSH, 4.5-10 mIU/L) or severe (TSH>10 mIU/L). While there is a general consensus to treat children with serum TSH levels above 10 mU/L, the management of the mild form is uncertain and should be individualized. In this mini-review, we present a brief review of SH in children based on extensive literature review and long-standing clinical experience. This review provides the prevalence, causes, clinical presentation, consequences, investigation, and up-to-date therapeutic approach of SH in children. Generally, the purpose of the review is to provide pediatricians with an update of this common and continuously evolving condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.