Evidence map›Paper›PMID 34218481›Full record

ArticleMolecular ecology2021

On the fixation or nonfixation of inversions under epistatic selection.

Brian Charlesworth, Thomas Flatt

Abstract read
In one paragraph

Article in Molecular ecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genomic architecture of supergenes: connecting form and function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian CharlesworthSchool of Biological Sciences, Institute of Evolutionary of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2706-355X
Thomas FlattDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID 0000-0002-5990-1503

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several recent publications have stated that epistatic fitness interactions cause the fixation of inversions that suppress recombination among the loci involved. Under this type of selection, however, the suppression of recombination in an inversion heterozygote can create a form of heterozygote advantage, which prevents the inversion from becoming fixed by selection. This process has been explicitly modelled by previous workers.

Indexed as

Epistasis, GeneticRecombination, GeneticChromosome InversionHeterozygoteHumansLinkage DisequilibriumModels, GeneticSelection, Geneticbalanced polymorphismepistasisfitnessinversionslinkage disequilibrium recombination suppression

Identifiers

PMID34218481
PMCPMC8456943

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.