Observational studyAmerican journal of reproductive immunology (New York, N.Y. : 1989)2021
Treatment following hysteroscopy and endometrial diagnostic biopsy increases the chance for live birth in women with chronic endometritis.
Observational study in American journal of reproductive immunology (New York, N.Y. : 1989), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Chronic Endometritis and Endometriosis: Two Sides of the Same Coin?Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Chronic endometritis and assisted reproduction: a systematic review and meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2023Pooled it
- Does antibiotic therapy for chronic endometritis improve clinical outcomes of patients with recurrent implantation failure in subsequent IVF cycles? A systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2022Pooled it
- A double-blind multi-centre randomised placebo-controlled trial of doxycycline in women with recurrent miscarriage and chronic endometritis defined by CD138 positive stromal cells.Human reproduction (Oxford, England) · 2026Trial
- CD138 expression in the endometrium associates with endometrial timing and inflammatory status but not microbiota composition.Human reproduction (Oxford, England) · 2026Trial
- Performance of hysteroscopy in diagnosing chronic endometritis and the role of intra- and inter-observer variability: a prospective study of 70 cases.AJOG global reports · 2025Article
- Article
- Risk factors of chronic endometritis in women who have undergone hysteroscopy: a prospective nested case-control study.Scientific reports · 2024Article
- Prevalence and confounders of chronic endometritis diagnosed using CD138 in patients with recurrent implantation failure.Clinical and experimental reproductive medicine · 2024Article
- Treatment following hysteroscopy and endometrial diagnostic biopsy increases the chance for live birth in women with chronic endometritis.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Observational
- Plasma Cell Counting Methodology Determines Chronic Endometritis Prevalence.Reproductive medicine and biologyArticle
- "Shortening time to pregnancy in infertile women by personalizing treatment of microbial imbalance through Emma & Alice: A multicenter prospective study".Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
problemRepeated implantation failure and recurrent pregnancy loss are associated with chronic endometritis, a persistent endometrial inflammation. Its diagnosis and treatment may increase pregnancy and live birth rates. The aim of this study was to assess the effectiveness of endometrial diagnostic biopsy and subsequent antibiotic treatment in cases of chronic endometritis on reproductive outcomes over a long observation period. METHOD OF STUDY: We conducted a historical cohort study (2014-2018) at our University-based infertility center that included women (n = 108) with repeated implantation failure or recurrent pregnancy loss without known pathologies associated with either condition. Forty-one women underwent a hysteroscopy only (reference group); the remaining 67 women underwent, in addition to the hysteroscopy, an endometrial diagnostic biopsy with immunohistochemically staining for CD138 to detect plasma cells (biopsy group). If one or more plasma cells were detected, the women were treated with doxycycline 100 mg twice a day orally for 2 weeks. We performed stratified survival analysis (Kaplan-Meier) and Cox regression.
resultsThe biopsy group had higher chances of pregnancy (hazard ratio 2.28; 95% confidence interval 1.23-4.24; p = .009) and of live birth (hazard ratio 2.76; 95% confidence interval 1.30-5.87; p = .008) compared with the reference group. In the sensitivity analysis, repeated implantation failure or recurrent pregnancy loss did not affect the outcome.
conclusionEndometrial diagnostic biopsy followed by antibiotic treatment in case of chronic endometritis in women with repeated implantation failure or recurrent pregnancy loss may increase the chances for live birth.
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