ArticleClinical transplantation2021
Aggressive pursuit and utilization of non-ideal donor lungs does not compromise post-lung transplant survival.
Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Differential Impact of Extended-Criteria Donor Use According to Recipient Status in Lung Transplantation: A Nationwide Cohort Study.Journal of Korean medical science · 2026Article
- Lung transplantation from donation after circulatory death donors over 55 years old: A national analysis of outcomes and utilization.JHLT open · 2026Article
- Impact of Mild-to-Moderate Donor Lung Infiltration on Post-lung Transplant Survival Outcomes and Risk Factors: A National Cohort Study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
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- Lungs From Donors ≥70 Years of Age for Transplantation-Do Long-Term Outcomes Justify Their Use?Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundOrgan procurement organizations (OPOs) vary in willingness to pursue and utilize non-ideal donor lungs; implications of these practices for lung transplant (LTx) recipients remain unclear. We examined associations between OPO-level behavior toward non-ideal donors and post-LTx outcomes.
methodsAdult lung donors and corresponding adult first-time LTx recipients in the 2008-2019 UNOS registry were included. Non-ideal donors had any of age > 50, smoking history ≥20 pack-years, PaO
resultsOf 22,795 recipients, 6229 (27.3%), 8256 (36.2%), and 8310 (36.5%) received lungs from least, moderately, and most aggressive OPOs, respectively. Moderately aggressive OPOs had the highest recipient rates of pre-discharge acute rejection, grade 3 primary graft dysfunction, postoperative extracorporeal membrane oxygenation, and longest lengths of stay. After adjustment, moderately and most aggressive OPOs had similar risks of recipient mortality as least aggressive OPOs.
conclusionsThe most and least aggressive OPOs achieve similar patient survival and short-term post-LTx outcomes. Aggressive pursuit and utilization of non-ideal donor lungs by less aggressive OPOs would likely expand the donor pool, without compromising recipient outcomes.
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