SynthesisNeurosurgical review2022
Natural history and treatment options of radiation-induced brain cavernomas: a systematic review.
Synthesis in Neurosurgical review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Radiation-induced cavernoma in pediatric CNS tumors: a systematic review and treatment paradigm.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Operative management of pediatric radiation-induced cavernous malformations: insights from a single-center cohort.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Radiation-induced meningiomas, cerebral aneurysm, and multiple cavernomas 2 decades after radiotherapy for medulloblastoma: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Case Report: longitudinal imaging in a patient with SMART syndrome after cranial radiotherapy.Frontiers in oncology · 2026Article
- Radiation-induced cavernous malformation arising within vestibular schwannoma manifesting as subarachnoid hemorrhage: Case report and literature review.Surgical neurology international · 2026Article
- Radiation-induced cavernous malformation in the brainstem after Gamma Knife radiosurgery for vestibular schwannoma: A case report and literature review.Brain & spine · 2026Article
- Radiation-Induced Cavernous Malformation in the Cerebellum: Clinical Features of Two Cases.Brain tumor research and treatment · 2025Article
- Radiation-induced cavernous malformation within a vestibular schwannoma: A case report.SAGE open medical case reports · 2025Article
- Unusual delayed postradiation vasculopathy mimicking tumour in an early adolescent with a remote history of metastatic medulloblastoma.BMJ case reports · 2024Article
- [Cavernous hemangioma of the cauda equina: A case report].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- A Potential Risk of Radiation-Induced Cavernous Malformations Following Adjuvant Gamma Knife Radiosurgery for Mesial Temporal Lobe Epilepsy.Journal of Korean Neurosurgical Society · 2024Article
- Neurologic Complications in Adult Cancer Survivorship.Seminars in neurology · 2024Article
- De novo meningiomas and cavernous malformations developing after coil embolization for dural arteriovenous fistula.Radiology case reports · 2024Article
- [Secondary tumors following radiation therapy and chemotherapy : Incidence of cavernous hemangiomas].Radiologie (Heidelberg, Germany) · 2023Review
- Chronic expanding hematoma of the left erector spinae muscle after stereotactic body radiotherapy for renal cell carcinoma: a case report.Journal of medical case reports · 2022Article
- Toxicity and Clinical Results after Proton Therapy for Pediatric Medulloblastoma: A Multi-Centric Retrospective Study.Cancers · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation-induced cavernous malformations (RICMs) are delayed complications of brain irradiation during childhood. Its natural history is largely unknown and its incidence may be underestimated as RCIMS tend to develop several years following radiation. No clear consensus exists regarding the long-term follow-up or treatment. A systematic review of Embase, Cochrane Library, PubMed, Google Scholar, and Web of Science databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was performed. Based on our inclusion/exclusion criteria, 12 articles were included, totaling 113 children with RICMs, 86 were treated conservatively, and 27 with microsurgery. We were unable to precisely define the incidence and natural history from this data. The mean age at radiation treatment was 7.3 years, with a slight male predominance (54%) and an average dose of 50.0 Gy. The mean time to detection of RICM was 9.2 years after radiation. RICM often developed at distance from the primary lesion, more specifically frontal (35%) and temporal lobe (34%). On average, 2.6 RICMs were discovered per child. Sixty-seven percent were asymptomatic. Twenty-one percent presented signs of hemorrhage. Clinical outcome was favorable in all children except in 2. Follow-up data were lacking in most of the studies. RICM is most often asymptomatic but probably an underestimated complication of cerebral irradiation in the pediatric population. Based on the radiological development of RICMs, many authors suggest a follow-up of at least 15 years. Studies suggest observation for asymptomatic lesions, while surgery is reserved for symptomatic growth, hemorrhage, or focal neurological deficits.
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