Evidence map›Paper›PMID 34218315›Full record

Trial reportEuropean journal of nutrition2022

Variation in urine osmolality throughout pregnancy: a longitudinal, randomized-control trial among women with overweight and obesity.

Asher Y Rosinger, Hilary J Bethancourt, Abigail M Pauley, Celine Latona, Jason John, Alysha Kelyman, Krista S Leonard, Emily E Hohman, Katherine McNitt, Alison D Gernand and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03945266 (Control Systems Engineering for Optimizing a Prenatal Weight Gain Intervention), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03945266 nacompletednot on this map

Control Systems Engineering for Optimizing a Prenatal Weight Gain Intervention

TypeinterventionalSponsorPenn State UniversityRan2014 to 2018Enrolled31ConditionsOverweight and Obesity, Physical Activity, Weight Change, Body, Eating BehaviorArmsIntervention group, Control group
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Asher Y RosingerDepartment of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA. arosinger@psu.edu.ORCID http://orcid.org/0000-0001-9587-1447
Hilary J BethancourtDepartment of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA.
Abigail M PauleyExercise Psychology Laboratory, Department of Kinesiology, Pennsylvania State University, University Park, PA, USA.
Celine LatonaDepartment of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA.
Jason JohnDepartment of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA.
Alysha KelymanDepartment of Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA.
Krista S LeonardExercise Psychology Laboratory, Department of Kinesiology, Pennsylvania State University, University Park, PA, USA.
Emily E HohmanCenter for Childhood Obesity Research, Pennsylvania State University, University Park, PA, USA.
Katherine McNittCenter for Childhood Obesity Research, Pennsylvania State University, University Park, PA, USA.
Alison D GernandDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.
Danielle Symons DownsExercise Psychology Laboratory, Department of Kinesiology, Pennsylvania State University, University Park, PA, USA.
Jennifer S SavageCenter for Childhood Obesity Research, Pennsylvania State University, University Park, PA, USA.
Pennsylvania State University · US

Funding

Population Research InstituteR24HD041025 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI LANDALE, NANCY S · 2001 to 2016
$9.7M
The Population Research Institute: Development CoreP2CHD041025 · NICHD · PENNSYLVANIA STATE UNIVERSITY, THE · PI Brian Thiede · 2016 to 2026
$9.0M
Control Systems Engineering for Optimizing a Prenatal Weight Gain InterventionR01HL119245 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI DOWNS, DANIELLE SYMONS · 2013 to 2017
$1.8M
Using Dynamical Systems Modeling to Understand the Effects of an Individually Tailored Prenatal Weight Gain Intervention on Fetal Growth and Postnatal Obesity RiskR56HL126799 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI WILLIAMS, JENNIFER SAVAGE · 2015 to 2015
$505k
National Institute of Child Health and Human Development P2CHD041025NHLBI NIH HHS 1R01H119245NHLBI NIH HHS R01 HL119245NHLBI NIH HHS R56 HL126799NICHD NIH HHS P2C HD041025NICHD NIH HHS R24 HD041025NIH HHS 1R56HL126799-01
6 · The paper itself

Abstract

purposeWater needs increase during pregnancy, and proper hydration is critical for maternal and fetal health. This study characterized weekly hydration status changes throughout pregnancy and examined change in response to a randomized, behavioral intervention. An exploratory analysis tested how underhydration during pregnancy was associated with birth outcomes.

methodsThe Healthy Mom Zone Study is a longitudinal, randomized-control trial intervention aiming to regulate gestational weight gain (GWG) in pregnant women with overweight/obesity (n = 27). Fourteen women received standard of care; 13 women additionally received weekly guidance on nutrition, physical activity, water intake, and health-promoting behaviors. Hydration status was measured weekly via overnight urine osmolality (Uosm) from ~ 8-36 weeks gestation; underhydration was dichotomized (Uosm ≥ 500 mOsm/kg). Gestational age- and sex-standardized birth weight and length z scores and percentiles were calculated. We used mixed-effect and linear regression models to test covariate-adjusted relationships.

resultsNo differences existed in Uosm or other characteristics between control and intervention women at baseline. Significant interactions (p = 0.01) between intervention and week of pregnancy on Uosm indicated intervention women maintained lower Uosm, whereas control women had a significant quadratic (inverse-U) relationship and greater Uosm in the second and early third trimesters. Results were consistent across robustness and sensitivity checks. Exploratory analyses suggest underhydration was associated with birth weight, but not length, in opposite ways in the second vs. third trimester.

conclusionA multi-component behavioral intervention helped women with overweight/obesity maintain better hydration throughout pregnancy. Future studies should confirm birth outcome results as they have important implications for early life nutrition.

trial registrationClinicalTrials.gov Identifier: NCT03945266; registered May 10, 2019 retrospectively.

Indexed as

Gestational Weight GainPregnancy ComplicationsFemaleHumansObesityOsmolar ConcentrationOverweightPregnancyRetrospective StudiesBirth outcomesDOHaDHydrationPregnancyUrine osmolalityWater intake

Identifiers

PMID34218315
PMCPMC8720908
OpenAlexW3178821318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.