Evidence map›Paper›PMID 34218006›Full record

ArticleDrug and alcohol dependence2021

Trends in psychotropic-drug-implicated mortality: Psychotropic drugs as a contributing but non-underlying cause of death.

Mike Vuolo, Laura C Frizzell, Brian C Kelly

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mike VuoloDepartment of Sociology, The Ohio State University, 236 Townshend Hall, 1885 Neil Avenue Mall, Columbus, OH, 43201, USA.
Laura C FrizzellDepartment of Sociology, The Ohio State University, 236 Townshend Hall, 1885 Neil Avenue Mall, Columbus, OH, 43201, USA.
Brian C KellyDepartment of Sociology, Purdue University, 700 W. State St, West Lafayette, IN, 47907, USA. Electronic address: bckelly@purdue.edu.

Funding

Effects of State-Level Policy Implementation on Opiate Abuse and MortalityR21DA046447 · NIDA · OHIO STATE UNIVERSITY · PI KELLY, BRIAN C, VUOLO, MICHAEL C · 2018 to 2019
$434k
NIDA NIH HHS R21 DA046447
6 · The paper itself

Abstract

backgroundDrug overdoses have contributed to considerable years of life lost. However, focusing solely on drug overdoses, whereby drug poisoning defines the underlying cause of death, obscures the wider burden of the drug mortality crisis. We aim to describe 21 years of trends in "psychotropic-drug-implicated deaths," those where psychotropic drugs are a contributing (but not the underlying) cause of death.

methodsWe analyze deaths extracted from CDC WONDER from 1999-2019 to generate annual counts and rates for psychotropic-drug-implicated deaths in the United States, including by underlying cause of death and drug implicated.

resultsOver 21 years, 51,446 psychotropic-drug-implicated deaths occurred (33,885 medical; 17,561 external). Both medical and external psychotropic-drug-implicated deaths rose dramatically, increasing 2.5 and 5.0 times, respectively. Diseases of the circulatory system predominated underlying causes of medical deaths (74 %). Non-drug suicide, transport accidents, and drownings constitute 54 % of external underlying causes. Among the various underlying causes of death, psychotropic-drug-implicated deaths represent a considerable proportion, especially among external causes, with the proportion greatly increasing over the observation period. The drug implicated evolves from cocaine to opioids to psychostimulants, with the latter rising considerably.

conclusionsThe drug mortality crisis extends beyond overdose and may temper improvements observed within other causes of mortality, such as cardiovascular disease, transport accidents, and drownings. As with overdoses, psychotropic-drug-implicated deaths have risen dramatically during the 21

Indexed as

Drug OverdosePharmaceutical PreparationsAnalgesics, OpioidCause of DeathHumansMortalityPsychotropic DrugsUnited StatesAnalgesics, OpioidPharmaceutical PreparationsPsychotropic DrugsDrugsMortalityOverdosePopulation health

Identifiers

PMID34218006
PMCPMC8355085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.