ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022
Obesity, Adiposity, and Risk of Symptomatic Gallstone Disease According to Genetic Susceptibility.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Association between albumin-bilirubin score and gallstones: exploring the potential mediating role of body mass index based on NHANES 2017-2020.Internal and emergency medicine · 2026Article
- Clinical characteristics of hospitalized patients with benign gallbladder disease: a large-scale retrospective analysis.BMC gastroenterology · 2026Article
- Denture use is associated with a higher risk of cholelithiasis: a prospective cohort study.BMC oral health · 2026Article
- Risk stratification for gallstones based on 14 obesity and lipid-related Indices: a longitudinal cohort study of 44,030 Chinese adults.Lipids in health and disease · 2026Article
- The U-shaped association between the metabolic score for insulin resistance and incident gallstone disease: a population-based cohort study.Frontiers in endocrinology · 2026Article
- Association between urinary cadmium levels and increased gallstone disease in US adults.Scientific reports · 2025Article
- The development and evaluation of nine obesity-based indices for gallstones in U.S. adults.International journal of surgery (London, England) · 2025Article
- Metabolic abnormalities, liver enzymes increased risk of gallstones: a cross-sectional study and multivariate mendelian randomization analysis.Internal and emergency medicine · 2025Article
- Cardiometabolic index as a predictor of gallstone incidence in U.S. adults: insights from NHANES 2017-2020.BMC gastroenterology · 2025Article
- Association of waist-to-hip ratio with risk of kidney stones in hypertensive population: a population-based cross-sectional study.Frontiers in endocrinology · 2025Article
- Association between advanced lung cancer inflammation index and gallstone prevalence among U.S. adults: A population-based study.PloS one · 2025Article
- The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Non-linear association of cardiometabolic index with gallstone disease in US adults: A cross-sectional study.PloS one · 2025Article
- Association between Neutrophil-to-high-density lipoprotein-cholesterol ratio and gallstones: insights from the national health and nutrition examination survey (2017-2020).Lipids in health and disease · 2024Article
- Long-term weight patterns and physical activity in gallstones.Scientific reports · 2024Article
- Association between life-ever gallstones and depressive symptoms in U.S. adults: a cross-sectional study.Scientific reports · 2024Article
- Association of education with cholelithiasis and mediating effects of cardiometabolic factors: A Mendelian randomization study.World journal of clinical cases · 2024Article
- Genetics of Gallstone Disease and Their Clinical Significance: A Narrative Review.Journal of clinical and translational hepatology · 2024Review
- Lipid accumulation product and gallstone risk in US adults: A cross-sectional analysis of NHANES 2017-2020 data.PloS one · 2024Article
- Higher triglyceride glucose-waist height ratio index is associated with higher prevalence of gallstone: a population-based study.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsAdiposity has been consistently associated with gallstone disease risk. We aimed to characterize associations of anthropometric measures (body mass index [BMI], recent weight change, long-term weight change, waist circumference, and waist-to-hip ratio) with symptomatic gallstone disease according to strata of gallstone disease polygenic risk score (PRS).
methodsWe conducted analysis among 34,626 participants with available genome-wide genetic data within 3 large, prospective, U.S. cohorts-the Nurses' Health Study (NHS), Health Professionals Follow-Up Study, and NHS II. We characterized joint associations of PRS and anthropometric measures and tested for interactions on the relative and absolute risk scales.
resultsWomen in the highest BMI and PRS categories (BMI ≥30 kg/m
conclusionsWhile maintenance of a healthy body weight reduces gallstone disease risk among all individuals, risk reduction is higher among the subset with greater genetic susceptibility to gallstone disease.
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