ArticleThe Journal of allergy and clinical immunology2021
Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors.
Article in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Socioeconomic status associates with worse asthma morbidity among Black and Latinx adults.The Journal of allergy and clinical immunology · 2022Trial
- Sequencing and health data resource of children of African ancestry.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Not all saliva samples are equal: The role of cellular heterogeneity in DNA methylation and epigenetic age analyses with biological and psychosocial factors.Psychoneuroendocrinology · 2026Article
- Social Determinants of Health in Pediatric Asthma and Allergic Diseases: A Systematic Review.Epidemiologia (Basel, Switzerland) · 2025Review
- Article
- Racial differences in odds of asthma exacerbations among Aspergillus fumigatus-sensitized adults with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025Article
- Social inequalities in childhood asthma.The World Allergy Organization journal · 2024Review
- Outdoor Air Pollution and Pediatric Respiratory Disease.Clinics in chest medicine · 2024Review
- Emergency management and asthma risk in young Medicaid-enrolled children with recurrent wheeze.The Journal of asthma : official journal of the Association for the Care of Asthma · 2024Article
- A novel tool using social and environmental determinants of health to assess pediatric asthma in the emergency department.Journal of the American College of Emergency Physicians open · 2024Article
- Article
- Place of death from asthma differs by age, race, and ethnicity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
- Multilevel Analysis of Racial and Ethnic Disparities in COVID-19 Hospitalization among Children with Allergies.Annals of the American Thoracic Society · 2023Article
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Race and Ethnicity in Pulmonary Function Test Interpretation: An Official American Thoracic Society Statement.American journal of respiratory and critical care medicine · 2023Article
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- Do upper respiratory viruses contribute to racial and ethnic disparities in emergency department visits for asthma?The Journal of allergy and clinical immunology · 2023Article
- New considerations of health disparities within allergy and immunology.The Journal of allergy and clinical immunology · 2023Review
- Immunogenetics and pharmacogenetics of allergic asthma in Africa.Frontiers in allergy · 2023Review
- Understanding racial disparities in childhood asthma using individual- and neighborhood-level risk factors.The Journal of allergy and clinical immunology · 2022Article
Corrections and comments
- Commented on by
- Erratum issuedCorrigendum.2022
Authors and funding
6 authors.
Funding
Abstract
backgroundSocial and financial hardships, combined with disease managment and environmental factors explain approximately 80% of the observed disparity in asthma-related readmissions between Black and White children.
objectiveWe sought to determine whether asthma-related readmissions differed by degree of African ancestry and the extent to which such an association would also be explained by socioenvironmental risk factors.
methodsThis study used data from a prospective cohort study of 695 Black and White children aged 1 to 16 years with an asthma-related admission. The primary outcome was a similar readmission within 12 months. Each subject's African ancestry was determined by single nucleotide polymorphisms on a continuous scale ranging from 0 to 1 (0 = no African ancestry; 1 = 100% African ancestry). We also assessed 37 social, environmental, and clinical variables that we clustered into 6 domains (for example, hardship, disease management). Survival and mediation analyses were conducted.
resultsA total of 134 children (19.3%) were readmitted within 12 months. Higher African ancestry was associated with asthma readmission (odds ratio 1.11, 95% confidence interval 1.05-1.18 for every 10% increase in African ancestry) with adjustment for age and gender. The association between African ancestry and readmission was mediated by hardship (sβ = 3.42, P < .001) and disease management (sβ = 0.046, P = .001), accounting for >50% of African ancestry's effect on readmission. African ancestry was no longer significantly associated with readmission (sβ = 0.035, P = .388) after accounting for these mediators.
conclusionsAfrican ancestry was strongly associated with readmission, and the association was mediated by family hardship and disease management. These results are consistent with the notion that asthma-related racial disparities are driven by factors like structural racism and social adversity.
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