ReviewNeuroscience and biobehavioral reviews2021
The nucleus reuniens orchestrates prefrontal-hippocampal synchrony during spatial working memory.
Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Choroid plexus cyst burden is associated with glymphatic dysfunction and cognitive impairment in hepatic encephalopathy.Hepatology communications · 2026Article
- Neuronal correlates of spatial memory updating: c-Fos and GAD67 expression in the object-place recognition task.Scientific reports · 2026Article
- Non-Canonical Subiculum Circuit Organization and Function.Hippocampus · 2026Review
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories.bioRxiv : the preprint server for biology · 2025Article
- Sparse memory ensembles set brain-wide network states to sustain learned associations.iScience · 2025Article
- Nucleus Reuniens-Elicited Delta Oscillations Disable the Prefrontal Cortex in Schizophrenia.Cells · 2025Review
- Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles.Human brain mapping · 2025Article
- Senescent Microglia Mediate Neuroinflammation-Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1.Aging cell · 2025Article
- Impaired theta and low-gamma directed information flow in the hippocampal-prefrontal circuit underlies working memory deficits in APP/PS1 mice.Behavioral and brain functions : BBF · 2025Article
- Article
- Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer's disease.Nature communications · 2025Article
- Temporal dynamics of cisplatin-induced endothelial senescence and its association with cognitive impairment: insights into the medial prefrontal cortex.Frontiers in oncology · 2025Article
- Alterations in Circular RNAs circOprm1 and circSerpini in the Striatum are Associated with Changes in Spatial Working Memory Performance after Morphine Dependence and Withdrawal in Rats.Neurochemical research · 2024Article
- Isolated theta waves originating from the midline thalamus trigger memory reactivation during NREM sleep in mice.Nature communications · 2024Article
- Article
- FNDC5/irisin mediates the protective effects of Innovative theta-shaking exercise on mouse memory.Heliyon · 2024Article
- Neural mechanisms of domain-general inhibitory control.Trends in cognitive sciences · 2023Review
- Projections from the five divisions of the orbital cortex to the thalamus in the rat.The Journal of comparative neurology · 2023Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Spatial working memory, the ability to temporarily maintain an internal representation of spatial information for use in guiding upcoming decisions, has been shown to be dependent upon a network of brain structures that includes the hippocampus, a region known to be critical for spatial navigation and episodic memory, and the prefrontal cortex (PFC), a region known to be critical for executive function and goal directed behavior. Oscillatory synchronization between the hippocampus and the prefrontal cortex (PFC) is known to increase in situations of high working memory demand. Most of our knowledge about the anatomical connectivity between the PFC and hippocampus comes from the rodent literature. Thus, most of the findings that will be discussed here model human working memory using spatial working memory-dependent maze navigation tasks in rodents. It has been demonstrated that the ventral midline thalamic nucleus reuniens (Re) is reciprocally connected to both the infralimbic and prelimbic subregions of the PFC, collectively referred to as the medial PFC (mPFC), and the hippocampus. Given that the Re serves as a major anatomical route between the mPFC and hippocampus, it is perhaps not surprising that Re has been shown to be critical for spatial working memory. This review will describe the latest findings and ideas on how the Re contributes to prefrontal-hippocampal synchronization and spatial working memory in rodents. The review will conclude with possible future directions that will advance the understanding of the mechanisms that enable the Re to orchestrate long range synchrony in the prefrontal-hippocampal network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.