Evidence map›Paper›PMID 34217588›Full record

SynthesisJournal of pediatric urology2021

The prognostic value of testicular microlithiasis as an incidental finding for the risk of testicular malignancy in children and the adult population: A systematic review. On behalf of the EAU pediatric urology guidelines panel.

Lisette A 't Hoen, Nikita R Bhatt, Christian Radmayr, Hasan S Dogan, Rien J M Nijman, Josine Quaedackers, Yazan F Rawashdeh, Mesrur S Silay, Serdar Tekgul, Raimund Stein and 1 more

Open access · hybridAbstract readSystematic Review
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In one paragraph

Synthesis in Journal of pediatric urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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  12. Pediatric Cancer Screening in Hereditary Gastrointestinal Cancer Risk Syndromes: An Update from the AACR Childhood Cancer Predisposition Working Group.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Lisette A 't HoenDepartment of Pediatric Urology, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: l.thoen@erasmusmc.nl.
Nikita R BhattDepartment of Urology, East of England Deanery, Urology, Cambridge, United Kingdom.
Christian RadmayrDepartment of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Hasan S DoganDivision of Pediatric Urology, Hacettepe University, Ankara, Turkey.
Rien J M NijmanDepartment of Urology and Pediatric Urology, University Medical Center Groningen, Rijks University Groningen, Groningen, the Netherlands.
Josine QuaedackersDepartment of Urology and Pediatric Urology, University Medical Center Groningen, Rijks University Groningen, Groningen, the Netherlands.
Yazan F RawashdehDepartment of Urology, Aarhus, Denmark.
Mesrur S SilayDivision of Pediatric Urology, Department of Urology, Istanbul Biruni University, Istanbul, Turkey.
Serdar TekgulDivision of Pediatric Urology, Hacettepe University, Ankara, Turkey.
Raimund SteinCenter for Pediatric, Adolescent and Reconstructive Urology, Medical Faculty Mannheim, University of Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Guy BogaertDepartment of Urology, University of Leuven, Leuven, Belgium.
Hacettepe University · TRUniversity Medical Center Groningen · NLBiruni University · TRErasmus MC · NLHeidelberg University · DEInnsbruck Medical University · ATKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe exact correlation of testicular microlithiasis (TM) with benign and malignant conditions remains unknown, especially in the paediatric population. The potential association of TM with testicular malignancy in adulthood has led to controversy regarding management and follow-up.

objectiveTo determine the prognostic importance of TM in children in correlation to the risk of testicular malignancy or infertility and compare the differences between the paediatric and adult population. STUDY

designWe performed a literature review of the Medline, Embase and Cochrane controlled trials databases until November 2020 according to the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) Statement. Twenty-six publications were included in the analysis.

resultsDuring the follow-up of 595 children with TM only one patient with TM developed a testicular malignancy during puberty. In the other 594 no testicular malignancy was found, even in the presence of risk factors. In the adult population, an increased risk for testicular malignancy in the presence of TM was found in patients with history of cryptorchidism (6% vs 0%), testicular malignancy (22% vs 2%) or sub/infertility (11-23% vs 1.7%) compared to TM-free. The difference between paediatric and adult population might be explained by the short duration of follow-up, varying between six months and three years. With an average age at inclusion of 10 years and testicular malignancies are expected to develop from puberty on, testicular malignancies might not yet have developed.

conclusionTM is a common incidental finding that does not seem to be associated with testicular malignancy during childhood, but in the presence of risk factors is associated with testicular malignancy in the adult population. Routine monthly self-examination of the testes is recommended in children with contributing risk factors from puberty onwards. When TM is still present during transition to adulthood a more intensive follow-up could be considered.

Indexed as

LithiasisTesticular DiseasesTesticular NeoplasmsUrologyAdultCalculiChildHumansIncidental FindingsMalePrognosisUltrasonographyCryptorchidismPaediatric urologyTesticular cancerTesticular microlithiasisTesticular ultrasoundTransition urology

Identifiers

PMID34217588
OpenAlexW3171381190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.