Evidence map›Paper›PMID 34217509›Full record

ArticleJournal of pediatric surgery2022

Efficacy of clinical-grade human placental mesenchymal stromal cells in fetal ovine myelomeningocele repair.

Christina M Theodorou, Sarah C Stokes, Jordan E Jackson, Christopher D Pivetti, Priyadarsini Kumar, Kaeli J Yamashiro, Zachary J Paxton, Lizette Reynaga, Alicia A Hyllen, Aijun Wang and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christina M TheodorouDepartment of Surgery, Division of Pediatric General, Thoracic, and Fetal Surgery, University of California Davis Medical Center, Sacramento, CA, United States; Surgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States. Electronic address: ctheodorou@ucdavis.edu.
Sarah C StokesDepartment of Surgery, Division of Pediatric General, Thoracic, and Fetal Surgery, University of California Davis Medical Center, Sacramento, CA, United States; Surgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Jordan E JacksonDepartment of Surgery, Division of Pediatric General, Thoracic, and Fetal Surgery, University of California Davis Medical Center, Sacramento, CA, United States; Surgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Christopher D PivettiSurgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Priyadarsini KumarSurgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Kaeli J YamashiroDepartment of Surgery, Division of Pediatric General, Thoracic, and Fetal Surgery, University of California Davis Medical Center, Sacramento, CA, United States; Surgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Zachary J PaxtonSurgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Lizette ReynagaSurgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Alicia A HyllenSurgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Aijun WangDepartment of Surgery, Division of Pediatric General, Thoracic, and Fetal Surgery, University of California Davis Medical Center, Sacramento, CA, United States; Surgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
Diana L FarmerDepartment of Surgery, Division of Pediatric General, Thoracic, and Fetal Surgery, University of California Davis Medical Center, Sacramento, CA, United States; Surgical Bioengineering Laboratory, University of California Davis Medical Center, Sacramento, CA, United States.
University of California Davis Medical Center · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Engineered Neuroprotective Stem-Cell Exosomes for In Utero Spina Bifida TherapyR01NS115860 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FARMER, DIANA LEE, WANG, AIJUN · 2020 to 2024
$2.5M
Fetal Tissue Engineering to Treat Spina Bifida Before BirthR01NS100761 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WANG, AIJUN · 2017 to 2021
$1.7M
NCATS NIH HHS UL1 TR001860NINDS NIH HHS R01 NS100761NINDS NIH HHS R01 NS115860
6 · The paper itself

Abstract

backgroundWhile fetal repair of myelomeningocele (MMC) revolutionized management, many children are still unable to walk independently. Preclinical studies demonstrated that research-grade placental mesenchymal stromal cells (PMSCs) prevent paralysis in fetal ovine MMC, however this had not been replicated with clinical-grade cells that could be used in an upcoming human clinical trial. We tested clinical-grade PMSCs seeded on an extracellular matrix (PMSC-ECM) in the gold standard fetal ovine model of MMC.

methodsThirty-five ovine fetuses underwent MMC defect creation at a median of 76 days gestational age, and defect repair at 101 days gestational age with application of clinical-grade PMSC-ECM (3 × 10

resultsClinical-grade PMSC-ECM lambs had significantly better motor function than ECM-only lambs (SLR 14.5 vs. 6.5, p = 0.04) and were similar to normal lambs (14.5 vs. 15, p = 0.2) and research-grade PMSC-ECM lambs (Group 1: 14.5 vs. 15, p = 0.63; Group 2: 14.5 vs. 14.5, p = 0.86; Group 3: 14.5 vs. 15, p = 0.50). Lumbar spine large neuron density was strongly correlated with motor function (r = 0.753, p<0.001).

conclusionsClinical-grade placental mesenchymal stromal cells seeded on an extracellular matrix rescued ambulation in a fetal ovine myelomeningocele model. Lumbar spine large neuron density correlated with motor function, suggesting a neuroprotective effect of the PMSC-ECM in prevention of paralysis. A first-in-human clinical trial of PMSCs in human fetal myelomeningocele repair is underway.

Indexed as

MeningomyeloceleMesenchymal Stem CellsAnimalsFemaleFetusGestational AgeHumansPlacentaPregnancySheepCellular therapyFetal surgeryMyelomeningoceleSpina bifida

Identifiers

PMID34217509
PMCPMC9365331
OpenAlexW3169151597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.