ArticleMicrobiome2021
Temporal patterns in Ixodes ricinus microbial communities: an insight into tick-borne microbe interactions.
Article in Microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- Feeding-state is associated with shifts in the Haemaphysalis bispinosa microbiome and its potential as a sentinel for circulating livestock pathogens.Veterinary research communications · 2026Article
- Adaptive restructuring of the microbiota promotes overwintering survival of the tick Dermacentor silvarum.Parasites & vectors · 2026Article
- Article
- Immune-mediated microbial interference governsiScience · 2026Article
- Ecological Frameworks of Pathogen-Pathogen and Pathogen-Microbiome Interactions Within the Tick Holobiont.Pathogens (Basel, Switzerland) · 2026Review
- Interaction between tick and host microbiotas: a four-step waltz.Parasites & vectors · 2026Review
- Spatiotemporal and tissue-specific dynamics of bacterial communities in adult femaleFrontiers in cellular and infection microbiology · 2026Article
- Genome-resolved metagenomics reveals microbiome diversity across 48 tick species.Nature microbiology · 2025Article
- Seasonal Variations in the Microbiome of Hyalomma excavatum Ticks in Algeria.Microbial ecology · 2025Article
- Diversity and spread of cytoplasmic incompatibility genes among maternally inherited symbionts.PLoS genetics · 2025Article
- Microbiome variation between male and female Hyalomma dromedarii ticks from camels in the UAE.Scientific reports · 2025Article
- Diversity of the Ixodes ricinus Microbiome Across Belgian Ecoregions and Its Association with Pathogen and Symbiont Presence.Microbial ecology · 2025Article
- MiCoDe: a web tool for performing microbiome community detection using a Bayesian weighted stochastic block model.Bioinformatics (Oxford, England) · 2025Article
- Host-Specificity and Network Structure of Tick Microbiota in Co-Distributed Species From the Iberian Peninsula.Ecology and evolution · 2025Article
- A Generalized Bayesian Stochastic Block Model for Microbiome Community Detection.Statistics in medicine · 2025Article
- Culturable bacteria and fungi in Ixodes, Dermacentor, Amblyomma and Ornithodoros ticks.Parasite (Paris, France) · 2025Article
- Differential Impact of Simultaneous or Sequential Coinfections WithInternational journal of microbiology · 2025Article
- Microbiome ofInsects · 2024Article
- Defining the bacterial microbiome of ticks in Chongwe and Chisamba Districts of Zambia.Infectious medicine · 2024Article
- Differential interactions of Rickettsia species with tick microbiota in Rh. sanguineus and Rh. turanicus.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTicks transmit pathogens of medical and veterinary importance and are an increasing threat to human and animal health. Assessing disease risk and developing new control strategies requires identifying members of the tick-borne microbiota as well as their temporal dynamics and interactions.
methodsUsing high-throughput sequencing, we studied the Ixodes ricinus microbiota and its temporal dynamics. 371 nymphs were monthly collected during three consecutive years in a peri-urban forest. After a Poisson lognormal model was adjusted to our data set, a principal component analysis, sparse network reconstruction, and differential analysis allowed us to assess seasonal and monthly variability of I. ricinus microbiota and interactions within this community.
resultsAround 75% of the detected sequences belonged to five genera known to be maternally inherited bacteria in arthropods and to potentially circulate in ticks: Candidatus Midichloria, Rickettsia, Spiroplasma, Arsenophonus and Wolbachia. The structure of the I. ricinus microbiota varied over time with interannual recurrence and seemed to be mainly driven by OTUs commonly found in the environment. Total network analysis revealed a majority of positive partial correlations. We identified strong relationships between OTUs belonging to Wolbachia and Arsenophonus, evidence for the presence of the parasitoid wasp Ixodiphagus hookeri in ticks. Other associations were observed between the tick symbiont Candidatus Midichloria and pathogens belonging to Rickettsia. Finally, more specific network analyses were performed on TBP-infected samples and suggested that the presence of pathogens belonging to the genera Borrelia, Anaplasma and Rickettsia may disrupt microbial interactions in I. ricinus.
conclusionsWe identified the I. ricinus microbiota and documented marked shifts in tick microbiota dynamics over time. Statistically, we showed strong relationships between the presence of specific pathogens and the structure of the I. ricinus microbiota. We detected close links between some tick symbionts and the potential presence of either pathogenic Rickettsia or a parasitoid in ticks. These new findings pave the way for the development of new strategies for the control of ticks and tick-borne diseases. Video abstract.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.