ArticleBMC genomics2021
Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae).
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Never underestimate honeybees: Their exceptionally diverse adaptive strategies.Journal of advanced research · 2026Review
- The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026Review
- Role of Long Non-Coding RNAs in Food Wanting ofInsects · 2025Article
- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- Long Non-Coding RNA LOC113219358 Regulates Immune Responses inInternational journal of molecular sciences · 2025Article
- Regulatory roles of long non-coding RNAs in short-term heat stress in adult worker bees.BMC genomics · 2024Article
- Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (International journal of molecular sciences · 2023Article
- Current Knowledge on Bee Innate Immunity Based on Genomics and Transcriptomics.International journal of molecular sciences · 2022Review
- Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient.iScience · 2022Article
- The Transcriptomic Landscape of Molecular Effects after Sublethal Exposure to Dinotefuran onInsects · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDinotefuran (CAS No. 165252-70-0), a neonicotinoid insecticide, has been used to protect various crops against invertebrate pests and has been associated with numerous negative sublethal effects on honey bees. Long noncoding RNAs (lncRNAs) play important roles in mediating various biological and pathological processes, involving transcriptional and gene regulation. The effects of dinotefuran on lncRNA expression and lncRNA function in the honey bee brain are still obscure.
resultsThrough RNA sequencing, a comprehensive analysis of lncRNAs and mRNAs was performed following exposure to 0.01 mg/L dinotefuran for 1, 5, and 10 d. In total, 312 lncRNAs and 1341 mRNAs, 347 lncRNAs and 1458 mRNAs, and 345 lncRNAs and 1155 mRNAs were found to be differentially expressed (DE) on days 1, 5 and 10, respectively. Gene set enrichment analysis (GSEA) indicated that the dinotefuran-treated group showed enrichment in carbohydrate and protein metabolism and immune-inflammatory responses such as glycine, serine and threonine metabolism, pentose and glucuronate interconversion, and Hippo and transforming growth factor-β (TGF-β) signaling pathways. Moreover, the DE lncRNA TCONS_00086519 was shown by fluorescence in situ hybridization (FISH) to be distributed mainly in the cytoplasm, suggesting that it may serve as a competing endogenous RNA and a regulatory factor in the immune response to dinotefuran.
conclusionThis study characterized the expression profile of lncRNAs upon exposure to neonicotinoid insecticides in young adult honey bees and provided a framework for further study of the role of lncRNAs in honey bee growth and the immune response.
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