Evidence map›Paper›PMID 34217207›Full record

ArticleEnvironmental health and preventive medicine2021

Seasonality of mortality under a changing climate: a time-series analysis of mortality in Japan between 1972 and 2015.

Lina Madaniyazi, Yeonseung Chung, Yoonhee Kim, Aurelio Tobias, Chris Fook Sheng Ng, Xerxes Seposo, Yuming Guo, Yasushi Honda, Antonio Gasparrini, Ben Armstrong and 1 more

Abstract read
In one paragraph

Article in Environmental health and preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. The Japanese Society of Hypertension Practical Consensus Guidelines for Seasonal Blood Pressure Management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Article
  4. Observational
  5. Review
  6. Seasonal Mortality and its Impact on Spatial Inequality in Life Expectancy Across Italy.European journal of population = Revue europeenne de demographie · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Global Population Exposure to Extreme Temperatures and Disease Burden.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lina MadaniyaziDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Yeonseung ChungDepartment of Mathematical Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
Yoonhee KimDepartment of Global Environmental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Aurelio TobiasSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Chris Fook Sheng NgSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Xerxes SeposoSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Yuming GuoDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Yasushi HondaFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Antonio GasparriniDepartment of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.
Ben ArmstrongDepartment of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.
Masahiro HashizumeDepartment of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan. hashizume@m.u-tokyo.ac.jp.

Funding

Medical Research Council MR/M022625/1Medical Research Council MR/R013349/1
6 · The paper itself

Abstract

backgroundAmbient temperature may contribute to seasonality of mortality; in particular, a warming climate is likely to influence the seasonality of mortality. However, few studies have investigated seasonality of mortality under a warming climate.

methodsDaily mean temperature, daily counts for all-cause, circulatory, and respiratory mortality, and annual data on prefecture-specific characteristics were collected for 47 prefectures in Japan between 1972 and 2015. A quasi-Poisson regression model was used to assess the seasonal variation of mortality with a focus on its amplitude, which was quantified as the ratio of mortality estimates between the peak and trough days (peak-to-trough ratio (PTR)). We quantified the contribution of temperature to seasonality by comparing PTR before and after temperature adjustment. Associations between annual mean temperature and annual estimates of the temperature-unadjusted PTR were examined using multilevel multivariate meta-regression models controlling for prefecture-specific characteristics.

resultsThe temperature-unadjusted PTRs for all-cause, circulatory, and respiratory mortality were 1.28 (95% confidence interval (CI): 1.27-1.30), 1.53 (95% CI: 1.50-1.55), and 1.46 (95% CI: 1.44-1.48), respectively; adjusting for temperature reduced these PTRs to 1.08 (95% CI: 1.08-1.10), 1.10 (95% CI: 1.08-1.11), and 1.35 (95% CI: 1.32-1.39), respectively. During the period of rising temperature (1.3 °C on average), decreases in the temperature-unadjusted PTRs were observed for all mortality causes except circulatory mortality. For each 1 °C increase in annual mean temperature, the temperature-unadjusted PTR for all-cause, circulatory, and respiratory mortality decreased by 0.98% (95% CI: 0.54-1.42), 1.39% (95% CI: 0.82-1.97), and 0.13% (95% CI: - 1.24 to 1.48), respectively.

conclusionSeasonality of mortality is driven partly by temperature, and its amplitude may be decreasing under a warming climate.

Indexed as

Cardiovascular DiseasesCause of DeathClimate ChangeCold TemperatureHot TemperatureHumansJapanMortalityRegression AnalysisRespiratory Tract DiseasesSeasonsTimeClimate changeMortalitySeasonalityTemperature

Identifiers

PMID34217207
PMCPMC8254906

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.