Evidence map›Paper›PMID 34217144›Full record

SynthesisDiabetes & metabolic syndrome

"Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis".

Dimple Rawat, Avishek Roy, Souvik Maitra, Vivek Shankar, Puneet Khanna, Dalim Kumar Baidya

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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  10. Does vitamin D supplementation reduce COVID-19 severity?: a systematic review.QJM : monthly journal of the Association of Physicians · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Dimple RawatClinical Epidemiology Unit, All India Institute of Medical Sciences, New Delhi, India. Electronic address: rawat.dimple96@gmail.com.
Avishek RoyDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: roy.avishek1992@gmail.com.
Souvik MaitraDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: souvikmaitra@live.com.
Vivek ShankarDepartment of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India. Electronic address: drshankarvivek@gmail.com.
Puneet KhannaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: k.punit@yahoo.com.
Dalim Kumar BaidyaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India. Electronic address: dalimkumar.ab8@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2.

methodsMeta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done.

resultsTotal 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01-4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01-7.89, p = 0.42).

conclusionNo significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic.

Indexed as

COVID-19 Drug TreatmentDietary SupplementsCOVID-19HumansNutrition TherapyPrognosisSARS-CoV-2Vitamin DVitaminsVitamin DVitaminsCOVID-19COVID pneumoniaSARS-CoV-2Vitamin-D

Identifiers

PMID34217144
PMCPMC8236412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.