Evidence map›Paper›PMID 34217122›Full record

ReviewCurrent opinion in biotechnology2021

RNAs - a new frontier in crop protection.

Dongdong Niu, Rachael Hamby, Jonatan Nino Sanchez, Qiang Cai, Qin Yan, Hailing Jin

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Review
  3. Toward sustainable control of phyto-nematodes: integrating lessons from crops to advance genetic modification in tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Current issues in molecular biology · 2025
    Article
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  9. Review
  10. Article
  11. Article
  12. Review
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  14. Article
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  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Dongdong NiuCollege of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China; Department of Microbiology & Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
Rachael HambyDepartment of Microbiology & Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
Jonatan Nino SanchezDepartment of Microbiology & Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
Qiang CaiState Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Qin YanCollege of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China.
Hailing JinDepartment of Microbiology & Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA. Electronic address: hailingj@ucr.edu.
University of California, Riverside · USNanjing Agricultural University · CNWuhan University · CN

Funding

Cross-kingdom RNA communications between plant and fungal pathogensR35GM136379 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI JIN, HAILING · 2020 to 2024
$2.1M
NIGMS NIH HHS R35 GM136379
6 · The paper itself

Abstract

Small RNA (sRNA)-mediated RNA interference (RNAi) is a regulatory mechanism conserved in almost all eukaryotes. sRNAs play a critical role in host pathogen interactions either endogenously or by traveling between the interacting organisms and inducing 'cross-Kingdom RNAi' in the counterparty. Cross-kingdom RNAi is the mechanistic basis of host-induced gene silencing (HIGS), which relies on genetically expressing pathogen-gene targeting RNAs in crops, and has been successfully utilized against both microbial pathogens and pests. HIGS is limited by the need to produce genetically engineered crops. Recent studies have demonstrated that double-stranded RNAs and sRNAs can be efficiently taken up by many fungal pathogens, and induce gene silencing in fungal cells. This mechanism, termed 'environmental RNAi', allows direct application of pathogen-gene targeting RNAs onto crops to silence fungal virulence-related genes for plant protection. In this review, we will focus on how we can leverage cross-kingdom RNAi and environmental RNAi for crop disease control.

Indexed as

Crop ProtectionCrops, AgriculturalRNA InterferenceRNA, PlantRNA, Small InterferingRNA, PlantRNA, Small Interfering

Identifiers

PMID34217122
PMCPMC8957476
OpenAlexW3177905068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.