Evidence map›Paper›PMID 34217071›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2021

COVID-19 Encephalitis with SARS-CoV-2 Detected in Cerebrospinal Fluid Presenting as a Stroke Mimic.

Diarmuid Glavin, Denise Kelly, Greta Karen Wood, Beth Ms McCausland, Mark Alexander Ellul, Aravinthan Varatharaj, Ian Galea, Rhys Huw Thomas, Benedict Daniel Michael, Brian Gallen and 1 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Diarmuid GlavinDepartment of Stroke Medicine, South West Acute Hospital, Enniskillen, Northern Ireland, UK.
Denise KellyDepartment of Stroke Medicine, South West Acute Hospital, Enniskillen, Northern Ireland, UK.
Greta Karen WoodDepartment of Clinical Infection Microbiology and Immunology, Institute of Infection, Veterinary, and Ecological Science, Liverpool, UK.
Beth Ms McCauslandClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK; University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Mark Alexander EllulDepartment of Clinical Infection Microbiology and Immunology, Institute of Infection, Veterinary, and Ecological Science, Liverpool, UK; Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK; The NIHR Health Protection Research Unit for Emerging and Zoonotic Infection, Liverpool, UK.
Aravinthan VaratharajClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK; University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Ian GaleaClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK; University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Rhys Huw ThomasTranslational and Clinical Research Institute, Newcastle University, Newcastle, UK; Department of Neurology, Royal Victoria Infirmary, Newcastle, UK.
Benedict Daniel MichaelDepartment of Clinical Infection Microbiology and Immunology, Institute of Infection, Veterinary, and Ecological Science, Liverpool, UK; Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK; The NIHR Health Protection Research Unit for Emerging and Zoonotic Infection, Liverpool, UK.
Brian GallenDepartment of Stroke Medicine, South West Acute Hospital, Enniskillen, Northern Ireland, UK. Electronic address: brian.gallen@westerntrust.hscni.net.
CoroNerve Study Management Group
University Hospital Southampton NHS Foundation Trust · GBUniversity of Liverpool · GBRoyal Victoria Infirmary · GBWestern Health and Social Care Trust · GB

Funding

Medical Research Council MC_UU_00004/04Medical Research Council MR/R017352/1Medical Research Council MR/T028750/1Medical Research Council MR/V007181/1Medical Research Council MR/V03605X/1
6 · The paper itself

Abstract

We report the case of a 35-year-old male with COVID-19 encephalitis presenting as a stroke mimic with sudden-onset expressive and receptive dysphasia, mild confusion and right arm incoordination. The patient received thrombolysis for a suspected ischaemic stroke, but later became febrile and SARS-CoV-2 was detected in cerebrospinal fluid. Electroencephalography demonstrated excess in slow waves, but neuroimaging was reported as normal. Respiratory symptoms were absent throughout and nasopharyngeal swab was negative for SARS-CoV-2. At the most recent follow-up, the patient had made a full neurological recovery. Clinicians should therefore consider testing for SARS-CoV-2 in CSF in patients who present with acute focal neurology, confusion and fever during the pandemic, even when there is no evidence of respiratory infection.

Indexed as

COVID-19 Nucleic Acid TestingAdultCOVID-19Diagnosis, DifferentialElectroencephalographyEncephalitis, ViralHumansIschemic StrokeMagnetic Resonance ImagingMalePredictive Value of TestsRNA, ViralSARS-CoV-2Tomography, X-Ray ComputedRNA, ViralCOVID-19EncephalitisSARS-Cov-2Stroke mimic

Identifiers

PMID34217071
PMCPMC8165128
OpenAlexW3169808983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.