Evidence map›Paper›PMID 34216993›Full record

ArticleBiochemical and biophysical research communications2021

UPR

Di Hu, Zunren Liu, Xin Qi

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Roles of mitophagy and immune infiltration in Parkinson's disease: new perspectives from bioinformatics analysis and A53T transgenic mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Di HuDepartment of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Zunren LiuDepartment of Biology, Case Western Reserve University College of Arts and Sciences, Cleveland, OH, 44106, USA.
Xin QiDepartment of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA; Center for Mitochondrial Disease, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. Electronic address: xxq38@case.edu.
University School · USCase Western Reserve University · US

Funding

Role of brain lipid metabolism in Alzheimer's diseaseR01AG065240 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2020 to 2024
$3.0M
Proteostasis dysregulation and alpha-synucleinR01NS115903 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2020 to 2023
$2.4M
Mitochondrial biomarkers in Huntington's diseaseR21NS107897 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2019 to 2019
$453k
NIA NIH HHS R01 AG065240NINDS NIH HHS R01 NS115903NINDS NIH HHS R21 NS107897
6 · The paper itself

Abstract

The pathogenesis of Parkinson's disease (PD) remains elusive, but mitochondrial dysfunction is believed to be one crucial step in its pathogenesis. The mitochondrial unfolded protein response (UPR

Indexed as

Models, Biological1-Methyl-4-phenylpyridiniumActivating Transcription FactorsCell Line, TumorCell SurvivalChaperonin 60Endopeptidase ClpGene ExpressionHumansMitochondriaMitochondrial ProteinsParkinson DiseaseProtective AgentsReactive Oxygen SpeciesUbiquitinsUnfolded Protein Response1-Methyl-4-phenylpyridiniumActivating Transcription FactorsATF5 protein, humanChaperonin 60ClpP protein, humanEndopeptidase ClpHSPD1 protein, humanMitochondrial ProteinsProtective AgentsReactive Oxygen SpeciesUbiquitinsUBL5 protein, humanATF5MPP(+)Parkinson's diseaseUPR(mt)

Identifiers

PMID34216993
PMCPMC8364872
OpenAlexW3176293837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.