Evidence map›Paper›PMID 34216819›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022

The Epidemiology of Microscopic Colitis in Olmsted County, Minnesota: Population-Based Study From 2011 to 2019.

June Tome, Kanika Sehgal, Amrit K Kamboj, William S Harmsen, Patricia P Kammer, Edward V Loftus, William J Tremaine, Sahil Khanna, Darrell S Pardi

Abstract read
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Update on the Epidemiology and Management of Microscopic Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. The natural history of histological changes in microscopic colitis.Therapeutic advances in gastroenterology · 2023
    Article
  13. Article
  14. Microscopic colitis in Northern Ireland: an updated clinicopathological audit and assessment of compliance with European guidelines.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022
    Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

June TomeDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Kanika SehgalDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Amrit K KambojDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
William S HarmsenDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
Patricia P KammerDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Edward V LoftusDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
William J TremaineDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Sahil KhannaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Darrell S PardiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: pardi.darrell@mayo.edu.

Funding

Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
NIA NIH HHS R01 AG034676NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

BACKGROUND &

aimsEpidemiologic studies from Europe and North America have reported an increasing incidence of microscopic colitis (MC) in the late 20th century, followed by a plateau. This population-based study assessed recent incidence trends and the overall prevalence of MC over the past decade.

methodsResidents of Olmsted County, MN, diagnosed with collagenous colitis (CC) or lymphocytic colitis (LC) between January 1, 2011, and December 31, 2019 were identified using the Rochester Epidemiology Project. Clinical variables were abstracted by chart review. Incidence rates were age- and sex-adjusted to the 2010 US population. Associations between incidence and age, sex, and calendar periods were evaluated using Poisson regression analyses.

resultsA total of 268 incident cases of MC were identified with a median age at diagnosis of 64 years (range, 19-90 y); 207 (77%) were women. The age- and sex-adjusted incidence of MC was 25.8 (95% CI, 22.7-28.9) cases per 100,000 person-years. The incidence of LC was 15.8 (95% CI, 13.4-18.2) and CC was 9.9 (95% CI, 8.1-11.9) per 100,000 person-years. A higher MC incidence was associated with increasing age and female sex (P < .01). There was no significant trend in age- and sex-adjusted incidence rate over the study period (P = .92). On December 31, 2019, the prevalence of MC, LC, and CC (including cases diagnosed before 2011) was 246.2, 146.1, and 100.1 per 100,000 persons, respectively.

conclusionsThe incidence of MC and its subtypes was stable between 2011 and 2019, but its prevalence was higher than in previous periods. The incidence of MC continues to be associated with increasing age and female sex.

Indexed as

Colitis, CollagenousColitis, LymphocyticColitis, MicroscopicFemaleHumansIncidenceMaleMinnesotaCollagenous ColitisEpidemiologyIncidenceLymphocytic ColitisMicroscopic ColitisPrevalence

Identifiers

PMID34216819
PMCPMC8716639

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.