Observational studyThe Canadian journal of cardiology2021
Biomechanical Modeling to Inform Pulmonary Valve Replacement in Tetralogy of Fallot Patients After Complete Repair.
Observational study in The Canadian journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- A modelling study of right ventricular growth with valvular regurgitation.Biomechanics and modeling in mechanobiology · 2026Article
- Patient-specific closed-loop model of the fontan circulation: Calibration and validation.Heliyon · 2024Article
- Tuning Into the Left Ventricle's Diastolic Dance Following Pulmonary Valve Replacement-Be Aware!Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- A biomechanics-based parametrized cardiac end-diastolic pressure-volume relationship for accurate patient-specific calibration and estimation.Scientific reports · 2023Article
- Prediction of Ventricular Mechanics After Pulmonary Valve Replacement in Tetralogy of Fallot by Biomechanical Modeling: A Step Towards Precision Healthcare.Annals of biomedical engineering · 2021Article
- Clinical Applications of Pressure-Volume Assessment in Congenital Heart Disease.Journal of the Society for Cardiovascular Angiography & InterventionsReview
- Direct assessment of total cavopulmonary connection power loss with interventional cardiac magnetic resonance in Fontan circulation.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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Authors and funding
11 authors at 3 institutions in 4 countries.
Funding
Abstract
backgroundA biomechanical model of the heart can be used to incorporate multiple data sources (electrocardiography, imaging, invasive hemodynamics). The purpose of this study was to use this approach in a cohort of patients with tetralogy of Fallot after complete repair (rTOF) to assess comparative influences of residual right ventricular outflow tract obstruction (RVOTO) and pulmonary regurgitation on ventricular health.
methodsTwenty patients with rTOF who underwent percutaneous pulmonary valve replacement (PVR) and cardiovascular magnetic resonance imaging were included in this retrospective study. Biomechanical models specific to individual patient and physiology (before and after PVR) were created and used to estimate the RV myocardial contractility. The ability of models to capture post-PVR changes of right ventricular (RV) end-diastolic volume (EDV) and effective flow in the pulmonary artery (Q
resultsRV contractility before PVR (mean 66 ± 16 kPa, mean ± standard deviation) was increased in patients with rTOF compared with normal RV (38-48 kPa) (P < 0.05). The contractility decreased significantly in all patients after PVR (P < 0.05). Patients with predominantly RVOTO demonstrated greater reduction in contractility (median decrease 35%) after PVR than those with predominant pulmonary regurgitation (median decrease 11%). The model simulated post-PVR decreased EDV for the majority and suggested an increase of Q
conclusionsThis study used a biomechanical model to synthesize multiple clinical inputs and give an insight into RV health. Individualized modeling allows us to predict the RV response to PVR. Initial data suggest that residual RVOTO imposes greater ventricular work than isolated pulmonary regurgitation.
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