ArticleCell2021
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
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Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers.
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188citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
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Who cites it
188 citing papers in PubMed, 286 citations in OpenAlex.
- Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.Cell reports. Medicine · 2023Trial
- Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review).Molecular medicine reports · 2026Review
- Methionine Regulates Antitumour Function of CD8Immunology · 2026Article
- Functional Characterization of the P-Type ATPases ATP13A3 and ATP13A4 as Plasma Membrane Polyamine Transporters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- SAT1-Induced Spermidine Depletion Potentiates Food Allergy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Butyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance.Nature communications · 2026Article
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- Polyamines in CNS malignancies: positively charged culprits in the hijacking of neural and immune signaling pathways.Amino acids · 2026Review
- HKDC1-mediated polyamine rewiring drives lenvatinib resistance and immune escape in hepatocellular carcinoma.Clinical and molecular hepatology · 2026Article
- Multiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction.Research square · 2026Article
- Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer.Nature immunology · 2026Article
- Metabolites as signalling molecules in the tumour immune microenvironment.Nature reviews. Immunology · 2026Review
- Integrated serum metabolomics and lipidomics for identifying metabolic changes in rheumatoid arthritis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
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- Review
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- IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Spermidine Suppresses Peripheral Inflammation and Alleviates Non-Motor Symptoms in the 6-OHDA-Induced Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland) · 2026Article
- Macrophage-intrinsic and IL-9-dependent arginine metabolism promotes lung tumor growth.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
128 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors at 9 institutions in 4 countries.
Daniel J PulestonMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; The Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
Francesc BaixauliMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
David E SaninMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Joy Edwards-HicksMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Matteo VillaMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Agnieszka M KabatMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Marcin M KamińskiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michal StanckzakMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Hauke J WeissMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Katarzyna M GrzesMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Klara PileticMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Cameron S FieldMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Mauro CorradoMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Fabian HaesslerMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Chao WangEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Yaarub MusaMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Lena SchimmelpfennigMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Lea FlachsmannMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Gerhard MittlerMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Nir YosefDepartment of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Vijay K KuchrooEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Joerg M BuescherMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Stefan BalabanovDivision of Haematology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Edward J PearceMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany; The Bloomberg∼Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Johns Hopkins University, Baltimore, MD, USA.
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Erika L PearceMax Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany; The Bloomberg∼Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Johns Hopkins University, Baltimore, MD, USA. Electronic address: epearce6@jhmi.edu.
Max Planck Institute of Immunobiology and Epigenetics · DESt. Jude Children's Research Hospital · USBroad Institute · USHarvard University · USSidney Kimmel Comprehensive Cancer Center · USUniversity of California, Berkeley · USUniversity of Freiburg · DEUniversity of Oxford · GBUniversity of Zurich · CH
Funding
Establishment, maintenance, and consequences of asymmetric cell division in T cellsR01AI123322 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 2017 to 2021
$2.2MNIAID NIH HHS R01 AI123322Wellcome Trust
Abstract
Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4
Indexed as
Cell LineageAnimalsCell DifferentiationCell PolarityCell ProliferationChromatinCitric Acid CycleColitisCytokinesDisease Models, AnimalEnzyme InhibitorsEpigenomeHistonesInflammationLymphocyte SubsetsLysineChromatinCytokinesEnzyme InhibitorsHistoneshypusineLysineOrnithine DecarboxylasePolyaminesTranscription FactorseIF5AhypusineimmunityimmunometabolismmetabolismpolyaminesT cells
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