ArticleAdvanced materials (Deerfield Beach, Fla.)2021
Reversible Photothermal Modulation of Electrical Activity of Excitable Cells using Polydopamine Nanoparticles.
Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The trial behind it
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Who cites it
32 citing papers in PubMed.
- Melanin-like Materials for Photothermal Applications: Recent Advancements and Future Directions.Molecules (Basel, Switzerland) · 2026Review
- circPVT1 regulates EMT and induces macrophage polarization to promotes the progression of renal cell carcinoma.Frontiers in immunology · 2026Article
- Nanotechnology for the Treatment of Radiation Dermatitis: Advances and Translational Perspectives.International journal of nanomedicine · 2026Review
- Neuroregulatory Biomaterials for Intervertebral Disc Regeneration via Neuro-Disc Microenvironment Modulation.Research (Washington, D.C.) · 2026Review
- Revolutionizing neural regeneration with smart responsive materials: Current insights and future prospects.Bioactive materials · 2025Review
- Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ultra-stretchable, adhesive and photothermal multifunctional hydrogel for renal denervation to treat hypertension.Materials today. Bio · 2025Article
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
- Simultaneous Detection of Neural Activity and Temperature in Photothermal Neural Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Musculoskeletal Organs-on-Chips: An Emerging Platform for Studying the Nanotechnology-Biology Interface.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Recent progress of polydopamine nanoparticles as advanced antimicrobial nanomaterials.Frontiers in bioengineering and biotechnology · 2025Review
- Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis.Renal failure · 2024Article
- Tetherless Optical Neuromodulation: Wavelength from Orange-red to Mid-infrared.Neuroscience bulletin · 2024Review
- Dynamic control of contractile resistance to iPSC-derived micro-heart muscle arrays.Journal of biomedical materials research. Part A · 2024Article
- Intracellular and extracellular synergistic therapy for restoring macrophage functions via anti-CD47 antibody-conjugated bifunctional nanoparticles in atherosclerosis.Bioactive materials · 2024Article
- The clinical prospects and challenges of photothermal nanomaterials in myocardium recovery after myocardial infarction.Frontiers in bioengineering and biotechnology · 2024Review
- The New Era of Neural Modulation Led by Smart Nanomaterials.International journal of nanomedicine · 2024Review
- Biocompatible copper formate-based nanoparticles with strong antibacterial properties for wound healing.Journal of nanobiotechnology · 2023Article
- Neuronal maturation-dependent nano-neuro interaction and modulation.Nanoscale horizons · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Advances in the design and synthesis of nanomaterials with desired biophysicochemical properties can be harnessed to develop non-invasive neuromodulation technologies. Here, the reversible modulation of the electrical activity of neurons and cardiomyocytes is demonstrated using polydopamine (PDA) nanoparticles as photothermal nanotransducers. In addition to their broad light absorption and excellent photothermal activity, PDA nanoparticles are highly biocompatible and biodegradable, making them excellent candidates for both in vitro and in vivo applications. The modulation of the activity (i.e., spike rate of the neurons and beating rate of cardiomyocytes) of excitable cells can be finely controlled by varying the excitation power density and irradiation duration. Under optimal conditions, reversible suppression (≈100%) of neural activity and reversible enhancement (two-fold) in the beating rate of cardiomyocytes is demonstrated. To improve the ease of interfacing of photothermal transducers with these excitable cells and enable spatial localization of the photothermal stimulus, a collagen/PDA nanoparticle foam is realized, which can be used as an "add-on patch" for photothermal stimulation. The non-genetic optical neuromodulation approach using biocompatible and biodegradable nanoparticles represents a minimally invasive method for controlling the activity of excitable cells with potential applications in nano-neuroscience and engineering.
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Registered trials
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