Evidence map›Paper›PMID 34216332›Full record

ArticleCellular and molecular neurobiology2022

Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability.

Alberto Granato, Adalberto Merighi

Abstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Defects of Cortical Microcircuits Following Early Exposure to Alcohol.Advances in experimental medicine and biology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alberto GranatoDepartment of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy. alberto.granato@unito.it.ORCID http://orcid.org/0000-0003-3755-1036
Adalberto MerighiDepartment of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy.ORCID http://orcid.org/0000-0002-1140-3556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here, we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction.

Indexed as

Intellectual DisabilityNeocortexDendritesHumansPyramidal CellsApical dendriteCalciumCerebral cortexDendritic spikeDown syndromeFetal alcohol

Identifiers

PMID34216332
PMCPMC8732981

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.